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  4. Recombinant Rat GTP-binding protein Rheb (Rheb)

Recombinant Rat GTP-binding protein Rheb (Rheb)

  • 中文名称：
    大鼠Rheb重组蛋白
  • 货号：
    CSB-YP733832RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rheb重组蛋白
  • 货号：
    CSB-EP733832RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rheb重组蛋白
  • 货号：
    CSB-EP733832RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rheb重组蛋白
  • 货号：
    CSB-BP733832RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rheb重组蛋白
  • 货号：
    CSB-MP733832RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rheb; GTP-binding protein Rheb; Ras homolog enriched in brain
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-181
  • 氨基酸序列
    MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF RRIILEAEKI DGAASQGKSS C
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
  • 基因功能参考文献：
    1. The regulation of Rheb-mTOR signal pathway. PMID: 29287199
    2. Our results suggest that panaxatriol derived from ginseng enhances resistance exercise-induced protein synthesis via mTORC1 signaling in rat skeletal muscle. PMID: 27865617
    3. Inhibition of miR-155 may play protective roles in ischemic stroke by phosphorylating S6K through the Rheb/mTOR pathway. PMID: 28025572
    4. Rheb activation disrupts neuronal spine synapse formation via syntenin accumulation in tuberous sclerosis complex. PMID: 25880340
    5. After spinal cord injury, expressing constitutively active Rheb increased the number of axons, but not the number of neurons, that projected into the peripheral nerve graft, indicative of augmented sprouting. PMID: 26245968
    6. In conclusion, dendritic spine abnormalities in TSC neurons may be caused through activation of Rheb, but not through of mTORC1. PMID: 24889507
    7. Suggest alteration of protein prenylation in cardiac hypertrophy induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure. PMID: 25385233
    8. Inactivation of Rheb protects cardiac myocytes during energy deprivation through activation of autophagy. PMID: 22294621
    9. REDD1 functions upstream of Tuberin and Rheb to down-regulate mTOR signaling in response to dexamethasone PMID: 17074751
    10. Rheb itself can activate both protein synthesis and cell growth in ARVC and demonstrate the key role played by mTORC1 in the growth of cardiomyocytes. PMID: 18722381
    11. Inhibition of PI3K or mTOR reduced the level of Rap1B, which acts downstream of Rheb and mTOR. The ubiquitin E3 ligase Smurf2 mediates the restriction of Rap1B by initiating its degradation. PMID: 18842593
    12. backbone assignments of activated Rheb in complex with the non-hydrolisable GTP analogue GppNHp PMID: 19636840

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  • 亚细胞定位：
    Endomembrane system; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Small GTPase superfamily, Rheb family
  • 组织特异性：
    Expressed at high levels in normal adult cortex as well as a number of peripheral tissues, including lung and intestine.
  • 数据库链接：

    KEGG: rno:26954

    STRING: 10116.ENSRNOP00000063915

    UniGene: Rn.859