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  4. Recombinant Rat Galanin-like peptide (Galp)

Recombinant Rat Galanin-like peptide (Galp)

  • 货号：
    CSB-YP009222RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009222RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009222RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009222RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009222RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Galp
  • Uniprot No.：
  • 别名：
    GalpGalanin-like peptide
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-83
  • 氨基酸序列
    APAHRGR GGWTLNSAGY LLGPVLHLSS KANQGRKTDS ALEILDLWKA IDGLPYSRSP RMT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological functions in CNS homeostatic processes, including the regulation of gonadotropin-releasing hormone secretion.
  • 基因功能参考文献：
    1. Hypothalamic galanin-like peptide rescues the onset of puberty in food-restricted weanling rats. PMID: 22681480
    2. present observations are consistent with the argument that galanin-like peptide (GALP) is a downstream effector of leptin's actions within the central nervous system PMID: 12586757
    3. This is the first study to demonstrate close apposition of galanin-like peptide (GALP)-immunoreactive cell bodies and GALP neurons expressing OX1-receptors in direct contact with orexin (OX1)-immunoreactive terminals in the arcuate nucleus. PMID: 12672543
    4. hypothalamic GALP gene expression is controlled by leptin signals and suggests possible involvement of GALP in the reproductive abnormalities of the Zucker obese rat. PMID: 12746327
    5. Cell activation induced by GALP in the supraoptic hypothalamic nucleus and nucleus tractus solitarius was dependent on food intake but independent of food consumption in all other brain regions. PMID: 12933672
    6. Leptin's activation of the sympathetic nervous system, and ultimately thermogenesis, may be partially mediated by GALP through a melanocortin-independent mechanism. PMID: 12960003
    7. Thyroidectomy led to a significant reduction in galanin-like peptide (GALP) mRNA expression. Expression of GALP mRNA was increased in the neurohypophysis of lactating rats, whereas GALP mRNA expression in the arcuate nucleus was unaffected by lactation. PMID: 14962070
    8. results have shown that STZ-induced diabetes, which suppresses leptin and insulin levels, results in a reduction of intracellular levels of GALP mRNA in the arcuate nucleus PMID: 15111492
    9. GALP gene expression in rats might be regulated by leptin-independent mechanisms. PMID: 15203243
    10. adaptive responses in GALP signaling might occur during chronic overfeeding PMID: 15944031
    11. observations demonstrate that endogenous Galanin-like peptide (GALP)provides trophic support to the neuroendocrine reproductive axis, including sexual behavior PMID: 16046316
    12. These results showed that acute osmotic stimulus-induced GALP gene expression in the pituicyte of the PP, but not in the neurons in the Arc, and the gene expression in the pituicyte is regulated by plasma osmolality and/or plasma sodium concentration. PMID: 17485169
    13. GALP-containing neurons innervate tuberoinfundibular dopaminergic neurons PMID: 17916390
    14. regulatory mechanism of GALP mRNA is different from that of the neuropeptide Y and proopiomelanocortin genes during postnatal development PMID: 17950941
    15. These data suggest that GALP activates feeding and sexual behaviors in male rats by stimulating dopaminergic neurons that terminate within the mPOA. PMID: 19124073

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Galanin family
  • 数据库链接：

    KEGG: rno:64568

    STRING: 10116.ENSRNOP00000038710

    UniGene: Rn.48754