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  4. Recombinant Rat Galectin-1 (Lgals1)

Recombinant Rat Galectin-1 (Lgals1)

  • 中文名称：
    大鼠Lgals1重组蛋白
  • 货号：
    CSB-YP012882RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Lgals1重组蛋白
  • 货号：
    CSB-EP012882RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Lgals1重组蛋白
  • 货号：
    CSB-EP012882RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Lgals1重组蛋白
  • 货号：
    CSB-BP012882RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Lgals1重组蛋白
  • 货号：
    CSB-MP012882RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Lgals1
  • Uniprot No.：
  • 别名：
    Lgals1; Galectin-1; Gal-1; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; RL 14.5; S-Lac lectin 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-135
  • 氨基酸序列
    ACGLVASNL NLKPGECLKV RGELAPDAKS FVLNLGKDSN NLCLHFNPRF NAHGDANTIV CNSKDDGTWG TEQRETAFPF QPGSITEVCI TFDQADLTIK LPDGHEFKFP NRLNMEAINY MAADGDFKIK CVAFE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
  • 基因功能参考文献：
    1. Stress-induced Gal-1 immediately accumulates in the spleen and thymus, and may modulate the immune response through apoptosis by binding to CD45(+) lymphocytes in immune organs following physiological and/or psychological stress. PMID: 27573167
    2. GAL1 has an essential role in HFD-induced obesity development. From a clinical viewpoint, pharmaceutical targeting of GAL1 using TDG and other inhibitor compounds would be a novel therapeutic approach for the treatment of obesity PMID: 25920776
    3. Galectin-1 protein is protective on in vivo and in vitro models of ocular inflammation. PMID: 26392742
    4. Galectin-1-binding glycoforms of haptoglobin PMID: 22028908
    5. Gal-1 regulates I(Ca,L) by decreasing the surface expression of Ca(V)1.2 channels in a splice variant selective manner. This may modulate vasoconstriction. Gal-1 binds the I-II loop only in the absence of alternatively spliced exon 9*. PMID: 21998324
    6. These results demonstrate that myenteric denervation downregulates endogenous Gal-1 and -3 expression, which might inhibit tumor development in this experimental model. PMID: 21188523
    7. The interaction of native dimeric and monomeric mutants of rat and human galectin-1 with mono- and divalent small molecules, fetuin, asialofetuin, and human serum glycoproteins was analyzed. PMID: 20873803
    8. Endogenous galectin-1 was found to be markedly upregulated, paralleled with increased astrocytic BDNF production under ischemic conditions both in vitro and in vivo. PMID: 20689988
    9. Expression of galectin-1 was remarkably up-regulated in activated astrocytes around cerebral ischemic infarct. PMID: 21054390
    10. Galectin-1 plays an important role in CD8+ T cell-mediated renal rejection by inducing immunological tolerance. PMID: 20298813
    11. Expression in testis was developmentally regulated, and its immunolabeling exhibited a stage-specific pattern throughout the spermatogenic process. PMID: 12493695
    12. it appears that galectin-1 and galectin-3 could participate in beta-galactoside binding and induce different intracellular signaling pathways leading to the proliferation of hepatocyte stellate cells PMID: 12646584
    13. Galectin-1 interacts with beta-1 subunit of integrin PMID: 14550305
    14. These data suggest that endogenous galectin-1 may potentiate neuropathic pain after the peripheral nerve injury at least partly by increasing SPR in the dorsal horn. PMID: 14642832
    15. the expression of galectin-1 in neurons correlates with the regenerative propensity. PMID: 15464279
    16. Analysis of galectin-1 signalling in pancreatic stellate cells revealed an activation of the extracellular signal-regulated kinases 1 and 2 and enhanced DNA binding of AP-1 transcription factors. PMID: 16038798
    17. In conclusion, our results suggest a role of galectin-1 in chemokine production and proliferation through its beta-galactoside binding activity in activated PSCs. PMID: 16373424
    18. point to a balanced expression of cell-associated-Gal-1/Gal-3 and might impact on the development of new therapeutic strategies for inflammatory diseases PMID: 16673152
    19. Gal-1 promotes H-Ras signaling to Raf . PMID: 16691442
    20. The results are compatible with a role for galectin-1 in facilitating reinnervation of denervated skeletal muscle. PMID: 18850073
    21. Galectin-1, a new component of slit diaphragm, is altered in minimal change nephrotic syndrome. PMID: 19079321

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Cytoplasm. Secreted.
  • 数据库链接：

    KEGG: rno:56646

    STRING: 10116.ENSRNOP00000013538

    UniGene: Rn.57