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  4. Recombinant Rat Gamma-aminobutyric acid receptor subunit beta-1 (Gabrb1), partial

Recombinant Rat Gamma-aminobutyric acid receptor subunit beta-1 (Gabrb1), partial

  • 中文名称：
    大鼠Gabrb1重组蛋白
  • 货号：
    CSB-YP009146RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Gabrb1重组蛋白
  • 货号：
    CSB-EP009146RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Gabrb1重组蛋白
  • 货号：
    CSB-EP009146RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Gabrb1重组蛋白
  • 货号：
    CSB-BP009146RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Gabrb1重组蛋白
  • 货号：
    CSB-MP009146RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Gabrb1
  • Uniprot No.：
  • 别名：
    Gabrb1; Gabrb-1Gamma-aminobutyric acid receptor subunit beta-1; GABA(A) receptor subunit beta-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
  • 基因功能参考文献：
    1. we conclude that is a greater contribution of beta(1) -subunit-containing GABA(A) receptors following oxygen and glucose deprivation in cerebellar Purkinje cells PMID: 23176253
    2. Bone marrow stem cells and adult stem cells were found to express GABA-A alpha2 and beta3, but not beta1 mRNA transcripts. PMID: 22215379
    3. The endogenous sleep pathway in the hypothalamus operates through the beta1- containing GABAAR whereas inhibition of neuronal firing (anaesthesia) by low propofol doses relies on beta3- containing GABAAR. PMID: 21735059
    4. Following spinal nerve ligation, activated microglia in the spinal cord modulate peripheral nerve injury-induced downregulation of GABA(B)R1a receptor expression in the spinal dorsal horn. PMID: 21242699
    5. beta1-containing GABA(A)Rs are expressed in the hypothalamus PMID: 20511229
    6. Activity-dependent bidirectional regulation of receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons. PMID: 11986365
    7. Results provide evidence for a conserved pore opening mechanism in anion-selective members of the ligand-gated ion channel family, including glycine receptors (GlyR) and gamma-aminobutyric acid, type A receptors (GABA(A)R). PMID: 12239220
    8. a serine at position 265 is critical in conferring an open state of the beta1 subunit-containing GABAA receptors in the absence of agonist PMID: 15014066
    9. GABA(B1) subunit mRNA signals were moderately expressed in the cerebral cortex neuroepithelium of discrete brain regions on gestational day (GD) 11.5 and 12.5 and were highly expressed in the brain and spinal cord on GD 13.5 and 15.5. PMID: 15158077
    10. Increased expression of GABA(A) receptor beta 1 subunit in the interneurones of the periaqueductal gray matter could render the panic circuitry abnormally excitable by disinhibiting ongoing GABAergic inhibition. PMID: 15708482
    11. falling progesterone levels may be associated with expression of new receptors of the alpha4beta1delta subtype in periaqueductal gray PMID: 15834956
    12. In rats with hepatic encephalopathy, mRNA expression levels of GABA(A) receptor subunits alpha(1), beta(1), gamma(2) increase significantly in basal nuclei, substantia nigra and hippocampi PMID: 15929193
    13. GABA(B) receptors expressed by neurones in solitary nucleus may be involved in cardiovascular regulation and that changes in GABA(B) mRNA expression levels may contribute to the hypertensive state in SHR PMID: 18338268

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB1 sub-subfamily
  • 数据库链接：

    KEGG: rno:25450

    STRING: 10116.ENSRNOP00000003170

    UniGene: Rn.207157