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  4. Recombinant Rat Lactadherin (Mfge8)

Recombinant Rat Lactadherin (Mfge8)

  • 货号：
    CSB-YP013752RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP013752RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP013752RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP013752RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mfge8; AgsLactadherin; MFGM; Milk fat globule-EGF factor 8; MFG-E8; O-acetyl GD3 ganglioside synthase; AGS; SED1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    23-427
  • 氨基酸序列
    ASGDFCDS SLCLNGGTCL MGQDNDIYCL CPEGFTGLVC NETEKGPCSP NPCFHDAKCL VTEDTQRGDI FTEYICQCPV GYSGIHCELG CSTKLGLEGG AIADSQISAS SVYMGFMGLQ RWGPELARLY RTGIVNAWTA SSYDSKPWIQ VDFLRKMRVS GVMTQGASRA GRAEYLKTFK VAYSLDGRRF EFIQDESGTG DKEFMGNQDN NSLKINMFNP TLEAQYIRLY PVSCHRGCTL RFELLGCELH GCSEPLGLKN NTIPDSQITA SSSYKTWNLR AFGWYPHLGR LDNQGKINAW TAQSNSAKEW LQVDLGTQKK VTGIITQGAR DFGHIQYVAS YKVAHSDDGV QWTVYEEQGT SKVFQGNLDN NSHKKNIFEK PFMARYVRVL PLSWHNRITL RLELLGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Appears to participate in the O-acetylation of GD3 ganglioside sialic acid.
  • 基因功能参考文献：
    1. beta-amyloid peptide induced neuronal loss is mediated by the bridging protein lactadherin/milk-fat globule epidermal growth factor-like factor 8 PMID: 23647050
    2. Liver and plasma MFG-E8 protein levels were significantly decreased after hepatic ischemia-reperfusion PMID: 22487387
    3. Performs important role in cell-cell binding, or in promoting phagocytosis. Specific localization of MFG-E8L(novel long form)in retinal pigment epithelium. PMID: 17167398
    4. These results suggested that lactadherin could adjust intestinal DCs activity, induce CD3(+)CD4(+)CD25(+)T cell differentiation, and enhance IL-10 production. PMID: 20379374
    5. study shows that OAcGD3S is strongly expressed during liver fibrogenesis and hepatic stellate cells seem to be the major cellular sources of OAcGD3S in the liver PMID: 12670504
    6. arterial MFG-E8 significantly increases with aging and is a pivotal relay element within the angiotensin II/MCP-1/VSMC invasion signaling cascade. PMID: 19443842

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  • 亚细胞定位：
    Membrane; Peripheral membrane protein. Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Peripheral membrane protein.
  • 组织特异性：
    Spleen, lung, heart, brain and muscle.
  • 数据库链接：

    KEGG: rno:25277

    UniGene: Rn.3742