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  4. Recombinant Rat Mannose-binding protein A (Mbl1)

Recombinant Rat Mannose-binding protein A (Mbl1)

  • 货号：
    CSB-YP324875RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP324875RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP324875RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP324875RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP324875RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mbl1
  • Uniprot No.：
  • 别名：
    Mbl1Mannose-binding protein A; MBP-A; Mannan-binding protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-238
  • 氨基酸序列
    SGS QTCEETLKTC SVIACGRDGR DGPKGEKGEP GQGLRGLQGP PGKLGPPGSV GAPGSQGPKG QKGDRGDSRA IEVKLANMEA EINTLKSKLE LTNKLHAFSM GKKSGKKFFV TNHERMPFSK VKALCSELRG TVAIPRNAEE NKAIQEVAKT SAFLGITDEV TEGQFMYVTG GRLTYSNWKK DEPNDHGSGE DCVTIVDNGL WNDISCQASH TAVCEFPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.
  • 基因功能参考文献：
    1. Our data show an important role for MBL in the pathogenesis of brain ischemic injury and provide a strong support to the concept that MBL inhibition may be a relevant therapeutic target. PMID: 22879370
    2. The expression of MBL was positively correlated with NF-kappaB expression in diabetic nephropathy. PMID: 21866632
    3. that the triple helical structure of the collagen-like domain is largely intact in the mutant proteins, but it is more easily unfolded than in wild-type MBP PMID: 14724269
    4. MASP-1 probably enhances complement activation triggered by MBP.MASP-2 complexes, but it cannot initiate activation itself PMID: 15060079
  • 亚细胞定位：
    Secreted. Note=According to PubMed:10903744, long retention times in the endoplasmic reticulum and the Golgi apparatus that have been observed in former studies may reflect the abnormal physiology of the hepatoma cells used.
  • 组织特异性：
    Detected in blood serum (at protein level).
  • 数据库链接：

    KEGG: rno:24548

    STRING: 10116.ENSRNOP00000015723

    UniGene: Rn.10273