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  4. Recombinant Rat Matrix metalloproteinase-14 (Mmp14), partial

Recombinant Rat Matrix metalloproteinase-14 (Mmp14), partial

  • 货号：
    CSB-YP608834RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP608834RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP608834RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP608834RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP608834RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mmp14; MtmmpMatrix metalloproteinase-14; MMP-14; EC 3.4.24.80; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT-MMP; MT1-MMP; MT1MMP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis.
  • 基因功能参考文献：
    1. The results suggest that MMP-14 is involved in proliferative diabetic retinopathy angiogenesis. PMID: 29853773
    2. expression of MMP-14 was different between cardiac isografts and allografts. MMP-14 could interact with CD44 in allografts. PMID: 27712978
    3. that MT1-MMP contributes to intestinal development, particularly to villi morphogenesis PMID: 27640084
    4. Downregulation of miR-193a-3p promoted loss of type II collagen by directly targeting MMP14 in IDD. miR-193a-3p inhibited IDD in vitro and in vivo. miR-193a-3p may be a promising candidate for prevention of degenerative disc disease. PMID: 26620678
    5. The MMP-1 is present in several brain areas in normal conditions at a detectable level, and its expression increases after kainate-induced seizures. PMID: 23683405
    6. Hepatic stellate cells acquired dependence on collagen for their growth during the transition from quiescent to active states. The intramolecular RGD motifs of collagen were exposed by cleavage with their own membrane type 1 matrix metalloproteinase. PMID: 24867951
    7. High MT1-MMP is associated with glomerulosclerosis in diabetic nephropathy. PMID: 21414971
    8. The MT1-MMP expression was widespread in the dental follicle. PMID: 21909755
    9. MT1-MMP was found in the cytoplasm of cells that may remodel the gubernaculum for eversion. It provides the collagenolysis necessary for migration through the inguinal fat pad. Disruption of these processes may cause cryptorchidism. PMID: 22152881
    10. MT1-MMP plays a crucial role in RAGE-activated NADPH oxidase-dependent signaling pathways. PMID: 20945382
    11. Sympathetic neurons express and secrete MMP-2 and MT1-MMP to control nerve sprouting via pro-NGF conversion. PMID: 20683769
    12. Data suggest that MT1-MMP and TIMP-2 may have some role in cell proliferation during the eruption of the rat incisor tooth. PMID: 20857180
    13. Addition of follicle stimulating hormone to Sertoli cells increased the MMP-14 mRNA level three-fold, implicating a role in spermatogenesis. PMID: 11928819
    14. may play a role in extracellular matrix degradation during periodontitis PMID: 12747454
    15. cross-talk between the hemopexin domain of MT1-MMP and adjacent cell surface molecules is responsible for outside-in signaling. PMID: 14729674
    16. MT1-MMP is not only important in matrix degradation but also may affect the function of focal adhesions through FAK cleavage. PMID: 15044209
    17. expression patterns indicate that MT1-MMP may play key role in uterine postpartum involution and subsequent functional regenerative processes PMID: 16740171
    18. The differentiation-dependent co-expression of Mmp14 with EMMPRIN in the enamel organ and in odontoblasts indicates that EMMPRIN takes part in the induction of proteolytic enzymes in the rat tooth germ. PMID: 17684756
    19. These data indicate that Indian hedgehog promotes pancreatic stellate cell migration by enhancing brane-type 1 matrix metalloproteinase localization on the plasma membrane but is negatively regulated by Gli-1. PMID: 18286538
    20. MT1-MMP has multiple functions and is implicated in multiple steps of the differentiation process, acting to regulate homeostasis of the osteogenic differentiation. PMID: 19027888

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Melanosome. Cytoplasm.
  • 蛋白家族：
    Peptidase M10A family
  • 数据库链接：

    KEGG: rno:81707

    STRING: 10116.ENSRNOP00000049168

    UniGene: Rn.10371