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  4. Recombinant Rat Myocyte-specific enhancer factor 2A (Mef2a)

Recombinant Rat Myocyte-specific enhancer factor 2A (Mef2a)

  • 货号：
    CSB-YP641752RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP641752RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP641752RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP641752RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP641752RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Mef2a; Myocyte-specific enhancer factor 2A
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-495
  • 氨基酸序列
    MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLAESSML SPPPATLHRN VSPGAPQRPP STGSAGGMLS TTDLTVPNGA GNGPVGNGFV DSRASPNLIG NTGANSVGKV MPTKSPPPPG GGSVGMNSRK PDLRVVIPPS SKGMMPPLNA QRISSSQATQ PLATPVVSVT TPSLPPQGLV YSAMPTAYNT DYSLTSADLS ALQGFTSPGM LSLGQASAWQ QHHLGQAALS SLVAGGQLSQ GSNLSINTNQ NINIKTEPIS PPRDRMTPSG FQQQQQQQPQ QQPPPQPPQP QPQPRQEMGR SPVDSLSSSS SSYDGSDRED PRGDFHSPIV LGRPPNAEDR ESPSVKRMRM DTWVT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
  • 基因功能参考文献：
    1. MEF2A participates in neuronal differentiation/maturation from neural stem cells. PMID: 29678571
    2. Animal physical conditioning increases hyper-acetylation of histones and increased the expression of NRF-1 and MEF2A genes. PMID: 28263745
    3. microRNAs encoded by the Gtl2-Dio3 noncoding RNA locus function downstream of the MEF2A PMID: 26240138
    4. The results of this study discovered a MEF2A-dependent transcriptional mechanism that plays an essential role in the regulation of presynaptic differentiation in the rat brain. PMID: 23486945
    5. These results give novel insight into the molecular interplay of GR and MEF2 in the control of genes important for neuronal plasticity. PMID: 22622902
    6. The Mef2A transcription factor coordinately regulates a costamere gene program in cardiac muscle. PMID: 21724844
    7. Muscle contraction leads to a rapid increase of MEF2A mRNA. PMID: 16024167
    8. findings report a requirement for MEF2A in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex PMID: 16484498
    9. PIASx is a MEF2A E3 ligase that promotes the differentiation of postsynaptic granule neuron dendrites in the cerebellar cortex. PMID: 17855618
    10. This study demonstrates for the first time extensive cytoplasmic localization of a MEF2 transcription factor in the mammalian brain in vivo PMID: 19362076

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: rno:309957

    STRING: 10116.ENSRNOP00000065122

    UniGene: Rn.162435