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  4. Recombinant Rat Myotrophin (Mtpn)

Recombinant Rat Myotrophin (Mtpn)

  • 中文名称：
    大鼠Mtpn重组蛋白
  • 货号：
    CSB-YP015195RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Mtpn重组蛋白
  • 货号：
    CSB-EP015195RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Mtpn重组蛋白
  • 货号：
    CSB-EP015195RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Mtpn重组蛋白
  • 货号：
    CSB-BP015195RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Mtpn重组蛋白
  • 货号：
    CSB-MP015195RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mtpn
  • Uniprot No.：
  • 别名：
    Mtpn; Gcdp; Myotrophin; Granule cell differentiation protein; Protein V-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-118
  • 氨基酸序列
    CDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTALEATDN QAIKALLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer. Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy.
  • 基因功能参考文献：
    1. Data provide evidence that the coherence of p53 with myotrophin plays an active role during the transition of cardiac hypertrophy to heart failure. PMID: 20202977
    2. Equilibrium folding and stability of myotrophin: a model ankyrin repeat protein. PMID: 12079376
    3. regulates catecholamine biosynthesis in a catecholaminergic phenotype-dependent manner PMID: 12297298
    4. role in controlling catecholamine secretion in PC12D cells PMID: 12387873
    5. V-1 expression is increased by hypertension in DS rat atrium. PMID: 12419325
    6. V-1 plays a role in prenatal muscle differentiation and postnatal muscle regeneration. PMID: 12467730
    7. expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
    8. stretching of cardiac myocytes by pressure or volume caused significant increase in the transcript levels of myotrophin , which in turn is responsible for the initiation process of myocardial hypertrophy PMID: 15532712
    9. Data strongly suggest that myotrophin appears to be a candidate gene for cardiac hypertrophy and heart failure. PMID: 15946807
    10. Results suggest that myotrophin V1 is a predominantly cytosolic protein that could regulate the NFkappa-beta mediated transcription process. PMID: 17041682
    11. characterisation of the small ankyrin repeat protein myotrophin PMID: 17113103
    12. after internalization into myocytes, myotrophin cotranslocates into the nucleus with p65 to stimulate myocyte growth. PMID: 18693253

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Myotrophin family
  • 数据库链接：

    KEGG: rno:79215

    STRING: 10116.ENSRNOP00000015808

    UniGene: Rn.3239