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  4. Recombinant Rat Neuroendocrine convertase 1 (Pcsk1)

Recombinant Rat Neuroendocrine convertase 1 (Pcsk1)

  • 中文名称：
    大鼠Pcsk1重组蛋白
  • 货号：
    CSB-YP017640RA
  • 规格：
    ￥2208
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Pcsk1
  • Uniprot No.：
  • 别名：
    Pcsk1; Bdp; Nec-1; Nec1Neuroendocrine convertase 1; NEC 1; EC 3.4.21.93; Prohormone convertase 1; Proprotein convertase 1; PC1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    Yeast
  • 分子量：
    73.2kDa
  • 表达区域：
    111-752aa
  • 氨基酸序列
    SVPRDSALNLFNDPMWNQQWYLQDTRMTASLPKLDLHVIPVWQKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDPTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLANNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECIIKDNNFEPRALKANGEVIVEIPTRACEGQENAINSLEHVQFEATIEYSRRGDLHVTLTSAAGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKVTDMSGRMQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVNVVEEKPTQNSLNGNLLVPKNSSSSSVEDRRDEQVQGAPSKAMLRLLQSAFSKNTPSKQSSKIPSAKLSVPYEGLYEALEKLNKPSQLEDSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEKN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
  • 基因功能参考文献：
    1. macrophages from PC1/3 KO mice and rat PC1/3-KD NR8383 macrophages secreted more pro-inflammatory cytokines such as TNF-alpha, IL6, IL1alpha and CXCL2. PMID: 26778167
    2. PC1/3 as an important regulator of vesicle trafficking and secretion in macrophages. PMID: 23637853
    3. Chronic ethanol exposure decreases prohormone convertase (pc1/3) immunoreactivity in brain. PMID: 23050949
    4. catalytic and P domains contribute to the folding and thermodynamic stability of the convertases through reciprocal hydrophobic interactions (prohormone convertase 3 [pc3/pc1]) PMID: 12721373
    5. The prohormone convertase (PC) enzyme PC1 together with PC2 and PC5 may represent a redundant system to ensure production of biologically active cholecystokinin in rat brain. PMID: 14608596
    6. proGHRH is initially cleave by furin at preproGHRH29-30, followed by a second cleavage at preproGHRH74 primarily by PC1 to generate GHRH and GHRH-RP peptides, respectively. PMID: 15146101
    7. Leptin regulates hypothalamic PC1 expression and requires prohormone processing into mature peptides. PMID: 15286802
    8. Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides PMID: 16204236
    9. the prohormone convertase cleavage site within the alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway PMID: 16221685
    10. The observed decrease in CCK seen with these RNAi treatments further supports a role for PC1 in CCK processing in these cells PMID: 16274843
    11. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132. PMID: 16384863
    12. These data indicate that the transmembrane domain of PC3 plays a key role in sorting the enzyme to the regulated secretory pathway. PMID: 17240044
    13. Ontogeny of ghrelin, obestatin, preproghrelin, and prohormone convertases in rat pancreas and stomach. PMID: 18784614

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  • 亚细胞定位：
    Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules.
  • 蛋白家族：
    Peptidase S8 family, Furin subfamily
  • 数据库链接：

    KEGG: rno:25204

    STRING: 10116.ENSRNOP00000015185

    UniGene: Rn.11384