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  4. Recombinant Rat Neuroligin-2 (Nlgn2), partial

Recombinant Rat Neuroligin-2 (Nlgn2), partial

  • 货号：
    CSB-YP723481RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP723481RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP723481RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP723481RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP723481RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlgn2
  • Uniprot No.：
  • 别名：
    Nlgn2; Neuroligin-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion.
  • 基因功能参考文献：
    1. e found that NLGN3 function at inhibitory synapses in rat CA1 depends on the presence of NLGN2 and identified a domain in the extracellular region that accounted for this functional difference between NLGN2 and 3 specifically at inhibitory synapses. PMID: 27805570
    2. Findings highlight peripuberty as a period that is highly vulnerable to stress, leading to the development of attention deficits and a dysfunction in the prefrontal cortex GABAergic system and NLGN-2 expression PMID: 26152839
    3. Studied the effect of clonal overexpression of NL3 and NL2 in neurons of the rat cerebral cortex in vivo after in utero electroporation PMID: 25565602
    4. Results highlight hippocampal NLGN-2 as a key molecular substrate regulating social behaviors and underscore NLGNs as promising targets for the development of novel drugs for the treatment of dysfunctional social behaviors PMID: 24213355
    5. Our data showed unexpected upregulation and pronociceptive effects of the "inhibitory" NL2 in neuropathic pain PMID: 23891900
    6. Data suggest nlgn2 in the hippocampus to be strongly implicated in maintaining the E/I balance in the brain and thereby modulating social and emotional behavior. PMID: 23451101
    7. The extracellular domain of neuroligin 2 confers its ability to enhance inhibitory synaptic function when expressed in hippocampal pyramidal neurons. PMID: 23426688
    8. Transcellular neuroligin-2 interactions enhance insulin secretion and are integral to pancreatic beta cell function PMID: 22528485
    9. these data suggest that intracellular mechanisms are involved in the targeting of different neuroligin family members such as Nlgn2 and Nlgn3 to synapses PMID: 19914352
    10. Study on the expression of NLGN2 in the developing and adult olfactory bulb PMID: 12141453
    11. The neuroligin 2 is found at synapses and also at GABAA receptor aggregates that are not facing presynaptic termini PMID: 15540461
    12. Neuroligin-neurexin link is a core component mediating both GABAergic and glutamatergic synaptogenesis, and differences in isoform localization and binding affinities may contribute to appropriate differentiation and specificity. PMID: 15620359
    13. Neuroligin 2 gene expression in the rat uterus is under the control of both E(2) and P(4), which are secreted periodically during the oestrous cycle. PMID: 15740699
    14. NL-2 may potentially serve as a central organizer for GABAergic synapse assembly by interacting with both presynaptic neurexins and postsynaptic GABA(A) receptors PMID: 17336090
    15. The retrograde response to axotomy of spinal motoneurons involves a rapid down-regulation of neuroligin 2 mRNA, indicating that down-regulation of synaptic adhesion molecules plays a role in postinjury synapse elimination. PMID: 17492651
    16. Data show beta-cell expression of the neuroligin 2, and show that neuroligin expression affects insulin secretion in INS-1 beta-cells and rat islet cells. PMID: 18755801
    17. we identified interactions of neuroligin 2 (NL2) with the key components of the inhibitory postsynaptic scaffold - gephyrin and collybistin; suggest that NL2 functions as an organizer of inhibitory postsynaptic differentiation PMID: 19755106

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Note=Detected at presynaptic membranes in retina, and at postsynaptic membranes in brain. Detected at dendritic spines in cultured neurons. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 组织特异性：
    Detected on hippocampus neurons, especially at inhibitory synapses. Detected in retina, in the outer and inner plexiform layer. Detected in pancreas, in islet of Langerhans beta cells (at protein level). Expressed in brain, spinal chord and dorsal root ga
  • 数据库链接：

    KEGG: rno:117096

    STRING: 10116.ENSRNOP00000053713

    UniGene: Rn.55111