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  4. Recombinant Rat Neuroligin-3 (Nlgn3), partial

Recombinant Rat Neuroligin-3 (Nlgn3), partial

  • 货号：
    CSB-YP737097RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP737097RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP737097RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP737097RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP737097RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nlgn3
  • Uniprot No.：
  • 别名：
    Nlgn3; Neuroligin-3; Gliotactin homolog
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.
  • 基因功能参考文献：
    1. show that up-regulation of BiP (immunoglobulin heavy-chain-binding protein) and CHOP [C/EBP (CCAAT/enhancer-binding protein)-homologous protein] was induced by both mutant proteins but not by wild-type neuroligin3 PMID: 26621873
    2. Studied the effect of clonal overexpression of NL3 and NL2 in neurons of the rat cerebral cortex in vivo after in utero electroporation, found that overexpression of NL3 has strong effects on GABAergic synapses and neuronal radial migration PMID: 25565602
    3. On a wild-type background, overexpression of a full-length version of NLGN3 yielded an increase in AMPA receptor (AMPAR)-evoked currents. PMID: 21532576
    4. Neuroligin 3 trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family. PMID: 20615874
    5. The retrograde response to axotomy of spinal motoneurons involves a rapid down-regulation of neuroligin 3 mRNA, indicating that down-regulation of synaptic adhesion molecules plays a role in postinjury synapse elimination. PMID: 17492651
    6. Rat NL3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. PMID: 17897391
    7. Data show beta-cell expression of the neuroligin 3, and show that neuroligin expression affects insulin secretion in INS-1 beta-cells and rat islet cells. PMID: 18755801

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Note=Detected at both glutamatergic and GABAergic synapses.
  • 蛋白家族：
    Type-B carboxylesterase/lipase family
  • 组织特异性：
    Detected in brain and on hippocampus neurons, especially at excitatory synapses. Detected in retina (at protein level). Expressed in brain, spinal chord and dorsal root ganglion.
  • 数据库链接：

    KEGG: rno:171297

    STRING: 10116.ENSRNOP00000005077

    UniGene: Rn.226139