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  4. Recombinant Rat Neuropeptide S (Nps)

Recombinant Rat Neuropeptide S (Nps)

  • 货号：
    CSB-YP016026RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016026RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016026RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016026RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016026RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nps
  • Uniprot No.：
  • 别名：
    Nps; Neuropeptide S
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    70-89
  • 氨基酸序列
    S FRNGVGSGVK KTSFRRAKQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations.
  • 基因功能参考文献：
    1. Neuropeptide S (NPS) increases motor activity and thermogenesis in the rat through sympathetic activation. These results suggest that NPS contributes to the regulation of the sympathetic nervous system. PMID: 28433253
    2. Intracerebroventricular (i.c.v.) NPS evoked a significant somatodendritic release of oxytocin within the paraventricular nucleus. The anxiolytic effects of NPS within the hypothalamic PVN are mediated via actions on local oxytocin neurons in male Wistar rats. PMID: 29118105
    3. Our study identified a protective role for NPS in amygdala against the development of NP, possibly attributing to its anti-inflammatory activity and inhibition of spinal microglia and astrocytes PMID: 27224019
    4. Present results suggest a selective activation of one of the three neuropeptide S-expressing neuron clusters as well as release of neuropeptide S in distinct forebrain regions after sleep deprivation. PMID: 26462664
    5. Single-dose and long-term (4 months) olanzapine treatment led to the upregulation of NPS expression in the rat hypothalamus. PMID: 26227793
    6. Results suggest that excitatory and inhibitory actions by the neuropeptide S system are integral to the depression in learned helplessness animals PMID: 25986404
    7. NPS activates histaminergic and orexinergic neurons, thereby promoting wakefulness. PMID: 22300983
    8. emotional stress-induced release of neuropeptide S in the amygdala supporting a functional role of endogenous NPS in stress/anxiety-related phenomena. PMID: 21861171
    9. data suggest a role for neuropeptide S in the modulation of ethanol drinking and possibly anxiety-like behavior in rats selectively bred for high alcohol drinking. PMID: 18564106
    10. These data demonstrate that the distribution pattern of the central neuropeptide S system is only partially conserved between mice and rats. PMID: 21452235
    11. NPS blocked cue-induced cocaine seeking, indicating a role for this system in the pathophysiology of drug relapse PMID: 20974945
    12. The results suggest that neuropeptide S mitigates spatial memory impairment in rats induced by 72-h REM sleep deprivation, possibly through activating cAMP-response element binding protein phosphorylation in the hippocampus. PMID: 20495497

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in mammary, salivary and thyroid gland. Expressed in the brain, in a cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus, as well as in few cells of the dorsomedial hypothalamic nucleus and the amygdala.
  • 数据库链接：

    KEGG: rno:100360071

    STRING: 10116.ENSRNOP00000051780

    UniGene: Rn.234299