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  4. Recombinant Rat Neuropeptide W (Npw)

Recombinant Rat Neuropeptide W (Npw)

  • 货号：
    CSB-YP016033RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP016033RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP016033RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP016033RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP016033RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Npw
  • Uniprot No.：
  • 别名：
    Npw; Ppl8; Neuropeptide W; Preproprotein L8; PPL8) [Cleaved into: Neuropeptide W-23; NPW23; L8); Neuropeptide W-30; NPW30; L8C)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    42-71
  • 氨基酸序列
    WYKHVASPR YHTVGRASGL LMGLRRSPYL W
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. When injected into the lateral cerebroventricle, it elevates prolactin (PRL) and corticosterone and lowers growth hormone (GH) release.
  • 基因功能参考文献：
    1. the effect and underlying mechanisms of NGF/BDNF on the production of NPW in PC12 cells and hypothalamus, is reported. PMID: 28249734
    2. NPW-producing neurones appear to participate in the hypothalamic mechanisms controlling prolactin (but not corticosterone) secretion PMID: 24028220
    3. These results strongly suggest that neuropeptide W may play an important central role in the feeding intake and energy balance control in mammals. PMID: 23510017
    4. The Neuropeptide W can affect glucose and lipid homeostasis, and food intake in rats. PMID: 22484289
    5. NPW and OB are not of primary importance in the short-term regulation of feeding behavior, but NPW may play a role in the long-term interactions between feeding and stress. PMID: 20624436
    6. Study indicates that NPW may play an important role in the regulation of feeding and energy metabolism. PMID: 20189998
    7. Our observations indicate that NPW-like immunoreactive neurons widely distributed in the rat brain region. PMID: 19948359
    8. Neuropeptide W effects on the hypothalamic-pituitary-adrenal axis. PMID: 15345475
    9. NPW directly activates beta-cells to enhance Ca(2+) influx through voltage-dependent L-type Ca(2+) channels and potentiates glucose-induced insulin release PMID: 17868932
    10. NPW is expressed in noradrenalin-containing cells in the adrenal medulla suggests that it may play an important role in endocrine function in the adrenal gland PMID: 17870191
    11. neuropeptide W is involved in the regulation of feeding and/or sleep/arousal behavior through orexin- and/or melanin-concentrating hormone-mediated neuronal pathways PMID: 17884195
    12. double immunohistochemistry demonstrated that neuropeptide W colocalized with gastrin in P1 rat stomach PMID: 17959264
    13. The central effects of NPW to inhibit growth hormone release results from activation of arcuate somatostatin neurons, which could result in an inhibition of GHRH-releasing neurons. PMID: 18285680
    14. The demonstration of particular phenotypic populations of paraventricular nucleus neurones showing NPW-23-induced effects on excitability reinforces the importance of the W/B neuropeptide system as a regulator of autonomic function. PMID: 19686447

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Neuropeptide B/W family
  • 数据库链接：

    KEGG: rno:259224

    STRING: 10116.ENSRNOP00000016554

    UniGene: Rn.14575