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  4. Recombinant Rat Neutrophil cytosol factor 2 (Ncf2)

Recombinant Rat Neutrophil cytosol factor 2 (Ncf2)

  • 货号：
    CSB-YP015528RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015528RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015528RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015528RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015528RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ncf2; Neutrophil cytosol factor 2; NCF-2; Neutrophil NADPH oxidase factor 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-527
  • 氨基酸序列
    MSLAEAIRLW NEGVQAADKK DWKGALEAFS EVQDPHSRIC FNIGCMYTIL DNLQEAEQAF TKSINRDKHL AVAYFQRGML YYSMEKYRPA SVGRKAALLF LGSYNLVARI IVGYPLSPGK VLYNIALMHA KKEEWKKAEE QLALATNMKS EPRHSKIDKA MESIWKRCPT SHLPLDPPQV TMALWFEEGG VGKRSVVASV VHQDNFSGFA PLQPQSAEPP PRPKTPEIFR ALEGEAHRVL FGFVPETPEE LQVMPGNIVF VLKKGSDNWA TVMFNGQKGL VPCNYLEPVE LRIHPQSQPQ EDTSLESDIP PPPNSSPPER LQLSPGWCQQ LGPLRCPPFL LHQEVKRSVP MPYMLKVHYK YTVVMETQLG LPYSQLRNMV SKKLELLPEH TKLSYQRRDS PELLLLSEES MKDAWAQVKN YCLTLWCEHT VGDQGFVDEP KEKENSDADN RTTEPQPKEG TQVVAIFSYD ATQPEDLEFV EGDVILVLSH VNEEWLEGEC KGKIGIFPKA FVEGCAAKNL EGTPREV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
  • 基因功能参考文献：
    1. p67(phox) subunit of NADPH oxidase 2 plays an important role in the excess production of ROS from mitochondria in the renal medulla of the Dahl salt-sensitive rat. PMID: 26062875
    2. when the p67(phox)subunit of nicotinamide adenine dinucleotide phosphate-oxidase is not functional in the salt-sensitive rats, high salt diet does not cause reduced renal medullary blood flow and salt-sensitive hypertension is attenuated PMID: 25489057
    3. The expression of NCF2 was upregulated after IL-4 treatment for 4 h, but it was downregulated after 8-24 h. It was suppressesd by amyloid beta or dbcAMP. PMID: 22565378
    4. Candesartan may protect neurons by decreasing extracellular glutamate immediately after reperfusion and by attenuating oxidative stress via a modulation of the AT1-R signaling that occurs during ischemic insult. PMID: 22661470
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    NCF2/NOXA1 family
  • 数据库链接：

    KEGG: rno:364018

    STRING: 10116.ENSRNOP00000060733

    UniGene: Rn.162331