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  4. Recombinant Rat Nuclear receptor subfamily 1 group I member 3 (Nr1i3)

Recombinant Rat Nuclear receptor subfamily 1 group I member 3 (Nr1i3)

  • 中文名称：
    大鼠Nr1i3重组蛋白
  • 货号：
    CSB-YP874096RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nr1i3重组蛋白
  • 货号：
    CSB-EP874096RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nr1i3重组蛋白
  • 货号：
    CSB-EP874096RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nr1i3重组蛋白
  • 货号：
    CSB-BP874096RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nr1i3重组蛋白
  • 货号：
    CSB-MP874096RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nr1i3
  • Uniprot No.：
  • 别名：
    Nr1i3; Car; Nuclear receptor subfamily 1 group I member 3; Constitutive androstane receptor; CAR
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-358
  • 氨基酸序列
    MTATLTLETM TSEEEYGPRN CVVCGDRATG YHFHALTCEG CKGFFRRTVS KTIGPICPFA GRCEVSKAQR RHCPACRLQK CLNVGMRKDM ILSAEALALR RARQARRRAQ KASLQLSQQQ KELIQTLLGA HTRHVGPMFD QFVQFRPPAY LFSHHRPFQP LAPVLPLLTH FADINTFMVQ QIIKFTKDLP LFRSLTMEDQ ISLLKGAAVE ILHISLNTTF CLQTQNFFCG PLCYKMEDAV HVGFQYEFLE LIIHFHKTLK RLQLQEPEYA LMAAMALFSP DRPGVTQREE IDQLQEEVAL ILNNHIMEQQ SRLQSRFLYA KLMGLLAELR SINSAYSYEI HRIQGLSAMM PLLGEICS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
  • 基因功能参考文献：
    1. nuclear expression virtually disappeared in the late stage of cholestatic injury, after an initial increase PMID: 29204052
    2. Metabolism of methiocarb and carbaryl does not alter CAR activity. PMID: 27665777
    3. results are the first report that CaR plays an important role in Ca(2+) signaling involved in cardiac fibrosis through the phospholipase C- inositol 3,4,5 phosphate (PLC-IP3) pathway. PMID: 24603056
    4. Dissociation of CAR nuclear receptor from thyroid hormone receptors results in down-regulation of hepatic cytochrome P450-PB2 (CYP2B)1. PMID: 24368200
    5. CAR nuclear receptors are activated following ethyl tertiary-butyl ether administration leading to tumorigenesis. PMID: 24090815
    6. Data show that nuclear import of CAR is regulated by importin/Ran-GTP systems. PMID: 20478346
    7. CAR expressed in the hepatic preneoplastic lesions of rats is resistant to nuclear translocation and transactivation of the phenobarbital(PB) responsive enhancer module upon PB treatment. PMID: 15953603
    8. Intracellular localization of CAR is determined by the combined effects of nuclear localization signals, the xenochemical response signal, and the cytoplasmic retention region. PMID: 16055207
    9. Constitutive CAR gene expression is regulated in part by CTP2B induction. PMID: 16153763
    10. In rat hepatocytes CAR was induced by WY14643, a PPARalpha-agonist. A DR1 motif in the CAR promoter was necessary and sufficient for this control. PMID: 18023279
    11. Evidence for the involvement of CAR in transcriptional effects upon perfluoroalkyl acid exposure in the rat is reported. PMID: 19162173
    12. CAR mRNA levels did not differ in the large-for-gestational-age rats PMID: 19435144

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Nuclear hormone receptor family, NR1 subfamily
  • 数据库链接：

    KEGG: rno:65035

    STRING: 10116.ENSRNOP00000048836

    UniGene: Rn.163229