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  4. Recombinant Rat Parvalbumin alpha (Pvalb)

Recombinant Rat Parvalbumin alpha (Pvalb)

  • 货号：
    CSB-YP019092RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019092RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019092RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019092RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019092RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Pvalb; Pva; Parvalbumin alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-110
  • 氨基酸序列
    SMTDLLSAE DIKKAIGAFT AADSFDHKKF FQMVGLKKKS ADDVKKVFHI LDKDKSGFIE EDELGSILKG FSSDARDLSA KETKTLMAAG DKDGDGKIGV EEFSTLVAES
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
  • 基因功能参考文献：
    1. The results of this study indicated that there are significantly more PV-positive neurons in the left basolateral amygdala compared to the right, with a significant difference specifically in the posterior subdivision. PMID: 29107660
    2. Peripubertal diazepam attenuated the decrease of parvalbumin in the ventral hippocampus of methylazoxymethanol acetate rats. PMID: 27432008
    3. NOX2 activation in the hippocampus, at least in part, contributes to oxidative stress and neuroinflammation, which further results in PV interneuron loss and consequent Post-traumatic stress disorder. PMID: 26650043
    4. enriched environment might prevent the juvenile hypoxia-induced developmental loss of PV cells in the prefrontal cortex and attenuate the neurobehavioral alterations through inhibition of NOX2-derived oxidative stress. PMID: 26698582
    5. Residues 49, 50, 57-60 were replaced with their counterparts from rat beta-parvalbumin. E59D, alone or with the other mutations, confers Ca2+ specificity on the CD site. PMID: 25553513
    6. In summary, our present study revealed a remarkable timing and topographic difference on the postnatal development of the nestin expression within the MS-DBB of BF compared with ChAT and PV expression. PMID: 24657285
    7. Calbindin and parvalbumin expression is lowest 3 weeks after streptozotocin administration to induce type 1 diabetes in rats. These deficits lead to disturbances in calcium homeostasis. PMID: 23628656
    8. The changes in the coexpression of perineuronal nets, parvalbumin and PTPsigma provide valuable insights into the connection between chondroitin sulfates and parvalbumin neurons. PMID: 23718120
    9. These results suggest the fact that the maintenance of parvalbumin expression is mediated to the neuroprotective function of nicotinamide against ischemic brain injury. PMID: 23047329
    10. Middle cerebral artery occlusion induced a reduction in parvalbumin transcript and protein levels. PMID: 22306612
    11. A significant neuronal loss in the globus pallidus of 6-OHDA-lesioned rats specifically affects parvalbumin-positive pallidal neurons. PMID: 23044920
    12. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks PMID: 23152631
    13. Studied the general pattern of calretinin (CR), parvalbumin (PV) and calbindin (CB) immunoreactivity as well as morphological features and density of CR and PV immunoreactive (CR+, PV+) interneurons in the rat perirhinal cortex (PRC) and found the PRC possesses specific interneuronal equipment with unusually high proportion of CR+ interneurons. PMID: 22221733
    14. The excitatory and inhibitory connections involving CA2 parvalbumin-positive basket cells are characterized for the first time. PMID: 20882544
    15. effects of estrogen on parvalbumin (PV) levels in cardiac myocytes of ovariectomized rats, which is a model system for postmenopausal woman PMID: 21411124
    16. results suggest that hypothyroidism ameliorated the diabetes-induced reduction of CB, CR, and PV immunoreactivity in the hippocampus PMID: 22037839
    17. Data indicate that the down-regulation of PV protein could participate in, at least in part, the modulation of nociceptive transmission. PMID: 21933624
    18. Parvalbumin protein expression in lumbar dorsal root ganglia is not affected by short repeated vibrations. PMID: 21561603
    19. Compared with normal rats, spinal isolation caused large decreases in tail muscle parvalbumin (95%), SERCA1 (70%) and SERCA2 (68%). PMID: 21930674
    20. Acute seizure activity-induced temporal lobe epilepsy in old age is associated with far fewer hippocampal NPY+ and PV+ interneuron numbers than AS-induced TLE in the young adult age. PMID: 21915341
    21. An enriched environment promotes increase in parvalbumin-positive cells in the peri-infarct cortex after permanent middle cerebral artery occlusion in rats. PMID: 20883785
    22. maternal separation causes a reduction of PVB and an increase in COX-2 expression in the prefrontal cortex, with concurrent working memory deficits. PMID: 21679927
    23. Unusual divalent ion-binding behavior associated with the beta-parvalbumin CD metal ion-binding site. PMID: 17198372
    24. Thus, depending on the region, NMDAR antagonism appears to influence expression of PV or GAD67, but not both. PMID: 19885653
    25. Results showed significant increase of protein level in the hippocampal formation and parvalbumin-immunoreactive neurons in CA1 and CA2/CA3 regions of rats submitted to exercise when compared with control rats. PMID: 19168302
    26. Data indicate that PV is down-regulated in the rat heart during aging. Data also indicate that long-term swimming exercise could induce an increase of PV expression. PMID: 19004479
    27. Study indicates that an increase of parvalbumin levels in the heart with increasing age may be associated with maintenance of proper relaxation of the cardiac myocytes needed to cope with the increasing workload of the heart during postnatal growth. PMID: 18977019
    28. 15N relaxation data for Ca(2+)-bound rat beta-parvalbumin (a.k.a. oncomodulin) were analyzed using the Lipari-Szabo formalism and compared with existing data for rat alpha-parvalbumin PMID: 11742132
    29. expression of calbindin-D28k and parvalbumin in the brainstem auditory pathway of homozygous recessive jaundiced (jj) Gunn rats was examined by light and electron microscopic immunohistochemistry PMID: 12204357
    30. Parvalbumin-positive cells likely comprise the cortically projecting GABAergic basal forebrain neurons. PMID: 12577320
    31. structure of metal ion-binding domains PMID: 12653564
    32. investigation of the impact of proline residues on parvalbumin stability PMID: 12974622
    33. AlphaPV mRNA begins expression before birth and remains highly expressed into the adult period. Immunoreactivity is expressed in both inner hair cells (IHCs) and OHCs of the organ of corti at birth. PMID: 14978725
    34. Rat alpha parvalbumin exhibits substantial affinity for Na+, but not K+, and competition by Na+ significantly attenuates divalent ion affinity. PMID: 15005610
    35. Xray crystallographic data for alpha-parvalbumin variant S55D/E59D reveals Asp-59 reacting to introduction of Asp-55 by withdrawing completely from the EF-hand coordination sphere, rotating away from Ca2+ and forming a hydrogen bond with the Glu-62 amide. PMID: 15287728
    36. The interaction between the beta-parvalbumin AB domain and beta-parvalbumin CD-EF domain may act to attenuate Ca2+ affinity in the intact protein. PMID: 15323551
    37. There is a reduction of inhibitory parvalbumin interneurons in the epileptic neocortex affected by cortical malformations as well as in morphologically unaffected epileptic temporal neocortex, thus representing a mechanism for their epileptogenicity. PMID: 16459206
    38. Parvalbumin- and calretinin-containing GABAergic neurons of the substantia nigra pars reticulata cannot be differentiated on the basis of their electrophysiological properties, morphological properties, or target nuclei. PMID: 17177263
    39. Upon Parv gene transfer, beta-Parv caused significantly faster relaxation than alpha-Parv in cardiac myocytes. PMID: 17545482
    40. Compared to socially housed rats, isolated rats exhibit deficits in prepulse inhibition of the startle reflex and reductions in parvalbumin and calbindin-immunoreactive cells in the hippocampus, with no significant change in calretinin. PMID: 17594127
    41. Data show the cardiac myocytes had Parvalbumin in their cytoplasm and intensity of PV immunoreactivity may be correlated with the physical activity of the heart. PMID: 17706751
    42. Comparison of calcium-bound and calcium-free alpha-parvalbumin structures. PMID: 18218708
    43. Report reduced parvalbumin expression in the spinal cord after peripheral inflammation. PMID: 18637710
    44. Contacts between medial and lateral perforant pathway fibers and parvalbumin expressing neurons in the subiculum of the rats. PMID: 18789377
    45. no change in somatic TRPV1 receptors and PV expression in L4 dorsal root ganglion neurons was found after peripheral inflammation PMID: 19397388
    46. Parvalbumin between Mg2+- and Ca2+-loaded states is different from the viewpoint of structural cooperativity of the two thermodynamic domains, which was clearly seen upon thermal denaturation. PMID: 19651438

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  • 蛋白家族：
    Parvalbumin family
  • 数据库链接：

    KEGG: rno:25269

    STRING: 10116.ENSRNOP00000058825

    UniGene: Rn.2005