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  4. Recombinant Rat Peptidyl-prolyl cis-trans isomerase D (Ppid)

Recombinant Rat Peptidyl-prolyl cis-trans isomerase D (Ppid)

  • 中文名称：
    大鼠Ppid重组蛋白
  • 货号：
    CSB-YP718748RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Ppid重组蛋白
  • 货号：
    CSB-EP718748RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Ppid重组蛋白
  • 货号：
    CSB-EP718748RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Ppid重组蛋白
  • 货号：
    CSB-BP718748RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Ppid重组蛋白
  • 货号：
    CSB-MP718748RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ppid; Peptidyl-prolyl cis-trans isomerase D; PPIase D; EC 5.2.1.8; 40 kDa peptidyl-prolyl cis-trans isomerase; Cyclophilin-40; CYP-40; Rotamase D
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-370
  • 氨基酸序列
    SHPSPAGKP SNSKNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGTGP TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGPNTNGS QFFITTVPTP HLDGKHVVFG QVIKGLGVAR MLENVEVNGE KPAKLCVIAE CGELKEGDEW GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LISEDLKNIG NTFFKSQNWE MAIKKYAKVL RYLDSSKAVI EKADVSRLQP IALSCVLNIG ACKLKMSNWQ GAIDSCLEAL EMDPSNTKAL YRKAQGWQGL KEYDQALADL KKAQEIAPGD KAIQAELLKV KQMIKAQKDK EKAVYAKMFA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity region. Involved in regulation of UV radiation-induced apoptosis.
  • 基因功能参考文献：
    1. cyclophilin D may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism PMID: 27864141
    2. Ppid expression was predicted by plasma estradiol & 34% lower in control adolescent females than males. After chronic adolescent stress, females had elevated hippocampal Ppid expression that was not seen in males. PMID: 22647578
    3. The effects of ethanol on the mitochondrial permeability transition pore and cyclophilin D expression in liver mitochondria are reported. PMID: 20651005
  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm.
  • 蛋白家族：
    Cyclophilin-type PPIase family, PPIase D subfamily
  • 数据库链接：

    KEGG: rno:361967

    STRING: 10116.ENSRNOP00000035797

    UniGene: Rn.136915