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  4. Recombinant Rat Peroxiredoxin-1 (Prdx1)

Recombinant Rat Peroxiredoxin-1 (Prdx1)

  • 货号：
    CSB-YP737225RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP737225RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP737225RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP737225RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP737225RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Prdx1; Tdpx2Peroxiredoxin-1; EC 1.11.1.15; HBP23; Heme-binding 23 kDa protein; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-199
  • 氨基酸序列
    SSGNAKIGH PAPSFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITINDLPVG RSVDEILRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVNK SKEYFSKQK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • 基因功能参考文献：
    1. Prdx1 inhibited MAPK pathway induced cells apoptosis, and reactive oxygen species is the upstream regulator of hypoxia/reoxygenation induced apoptosis. PMID: 29410271
    2. peroxiredoxin 1 has a role in redox sensing and transducing [review] PMID: 27756681
    3. Increased expression of Prdx1 was identified in astrocytes and microglia following traumatic spinal cord injury. PMID: 26003307
    4. Prx1 may alleviate renal tubulointerstitial fibrosis by inhibiting oxidative stress induced apoptosis via p38 MAPK pathway. PMID: 25989822
    5. Prdx 1 expression increased during late gestation & peaked at postnatal-day 1, when its expression gradually decreased. It was strongly expressed in the corpus callosum. PMID: 22166015
    6. peroxiredoxin I gene expression is activated via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway PMID: 12960165
    7. mammalian sulfiredoxin reactivates hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine PMID: 15448164
    8. the complementary hepatic gene expression pattern of HO-1 and Prx I in response to oxidative stress may suggest a functional interplay of these antioxidant genes PMID: 16309569
    9. hippocampal neurons transfected with wild type Prx1 exhibit increased Abeta resistance PMID: 17761673
    10. X-ray diffraction analysis showed HBP23/Prx I has a Cys(83)-Cys(83) disulfide bond at only one dimer-dimer interface, whereas the interactions at the other interfaces appear to involve hydrophobic and van der Waals forces. PMID: 17974571

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 数据库链接：

    KEGG: rno:117254

    STRING: 10116.ENSRNOP00000023132

    UniGene: Rn.2845