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  4. Recombinant Rat Phosphatidylethanolamine-binding protein 1 (Pebp1)

Recombinant Rat Phosphatidylethanolamine-binding protein 1 (Pebp1)

  • 货号：
    CSB-YP017766RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017766RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP017766RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017766RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP017766RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pebp1
  • Uniprot No.：
  • 别名：
    Pebp1; Pbp; Pebp; Phosphatidylethanolamine-binding protein 1; PEBP-1; 23 kDa morphine-binding protein; HCNPpp; P23K) [Cleaved into: Hippocampal cholinergic neurostimulating peptide; HCNP)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-187
  • 氨基酸序列
    AADISQWAG PLSLQEVDEP PQHALRVDYG GVTVDELGKV LTPTQVMNRP SSISWDGLDP GKLYTLVLTD PDAPSRKDPK FREWHHFLVV NMKGNDISSG TVLSEYVGSG PPKDTGLHRY VWLVYEQEQP LNCDEPILSN KSGDNRGKFK VESFRKKYHL GAPVAGTCFQ AEWDDSVPKL HDQLAGK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation.; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor.
  • 基因功能参考文献：
    1. RKIP attenuates ischemia-induced microglia cell apoptosis and activation through NF-kappaB pathway. PMID: 28245468
    2. Loss of RKIP may be associated with malignant progression in hepatic fibrosis. PMID: 27470410
    3. Raf-1 kinase inhibitory protein plays an important role in the neural cell apoptosis induced by microwave radiation PMID: 25108669
    4. RKIP overexpression increases cardiac contractility mediated by the beta1-adrenoceptor. RKIP deficiency exaggerates pressure overload-induced cardiac failure. PMID: 26479924
    5. PEBP1, given its synaptic localization and its role as a signaling molecule acting via the ERK/MAPK pathway, could be a potential therapeutic target mediating drug-seeking behaviors associated with neuroinflammation. PMID: 25962787
    6. LTD4 inhibits ASCT1 through PKC-mediated phosphorylation of RKIP, leading to the subsequent activation of PKA pathway, possibly through beta2-andrenergic receptor activation. PMID: 25231108
    7. These results suggest that expression levels of RKIP might be regulated by RTX via NF-kappaB PMID: 24065653
    8. Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells PMID: 22859298
    9. These findings suggest that HCNP, in association with CRMP-2, plays an important role in presynaptic function in the hippocampus PMID: 22542739
    10. RKIP in the hippocampus is downregulated by electromagnetic radiation. PMID: 19309582
    11. Decreased PEBP1 expression correlates with subsequent activation of mitogen-activated protein (MAP) kinase signaling components of the MAP kinase cascade. PMID: 21554319
    12. Study suggest that PEBP and C11orf59 might be involved in controlling lipid or carbohydrate metabolism in diabetes via PPARalpha activation. PMID: 20510017
    13. Data suggest that lowered expression of PEBP1 might be responsible for dementia associated with high-altitude hypoxia. PMID: 19705086
    14. The excessive activation of RKIP mediated ERK pathway is one of the important mechanisms for the apoptosis and death of hippocampus neurons induced by electromagnetic radiation. PMID: 18616905
    15. selective modulation of c-Raf-1 but not B-Raf activation by RKIP can limit the dynamic range of the MAPK signaling response to growth factors and may play a critical role in growth and development PMID: 15886202
    16. These results indicate that RKIP regulates Aurora B kinase and the spindle checkpoint via the Raf-1/MEK/ERK cascade and demonstrate that small changes in the MAP kinase (MAPK) pathway can profoundly impact the fidelity of the cell cycle. PMID: 16916643
    17. PEBP1 may be a novel molecular mediator influencing cognitive integrity during chronic corticosterone exposure in rat hippocampus. PMID: 18311602
    18. Raf kinase inhibitor protein inhibits ERK/MAPK signalling and this inhibition impedes HSC proliferation. RKIP promotes HSC migration and wound closure. PMID: 19323783
    19. Receptor distribution in crude brain membrane fractions and similarity in distribution patterns between binding site and HCNP-precursor protein mRNA expression suggest that HCNP exerts its functions near the dendrites of the neurons that produce it. PMID: 12591138

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  • 亚细胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Phosphatidylethanolamine-binding protein family
  • 组织特异性：
    Major component of epididymal secretions and sperm plasma membranes. It is present in cytosols from a variety of other tissues. Highly expressed in brain.
  • 数据库链接：

    KEGG: rno:29542

    STRING: 10116.ENSRNOP00000001500

    UniGene: Rn.29745