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  4. Recombinant Rat Phosphatidylinositol transfer protein alpha isoform (Pitpna)

Recombinant Rat Phosphatidylinositol transfer protein alpha isoform (Pitpna)

  • 货号：
    CSB-YP018035RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018035RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018035RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018035RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018035RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Pitpna
  • Uniprot No.：
  • 别名：
    Pitpna; Pitpn; Phosphatidylinositol transfer protein alpha isoform; PI-TP-alpha; PtdIns transfer protein alpha; PtdInsTP alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-271
  • 氨基酸序列
    VLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DDGEKGQYTH KIYHLQSKVP TFVRMLAPEG ALNIHEKAWN AYPYCRTVIT NEYMKEDFLI KIETWHKPDL GTQENVHKLE PEAWKHVEAI YIDIADRSQV LSKDYKAEED PAKFKSIKTG RGPLGPNWKQ ELVNQKDCPY MCAYKLVTVK FKWWGLQNKV ENFIHKQEKR LFTNFHRQLF CWLDKWVDLT MDDIRRMEEE TKRQLDEMRQ KDPVKGMTAD D
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the transfer of phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes. Shows a preference for PI and PC containing shorter saturated or monosaturated acyl chains at the sn-1 and sn-2 positions. Preference order for PC is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 and for PI is C16:1 > C16:0 > C18:1 > C18:0 > C20:4 > C20:3.
  • 基因功能参考文献：
    1. Data suggest that (1) interaction of Pitpna with membrane/lipid bilayer is spontaneous and mediated by four specific protein substructures; (2) ability of Pitpna to initiate closure around PC ligand is accompanied by loss of flexibility of two helix/loop regions, as well as of C-terminal helix; (3) energy barrier of PC/PI extraction from membrane is lowered by hydrogen bonding between lipid and Pitpna. PMID: 28718450
    2. Lower protein expression of PI-TP(alpha and beta) in aged brain and in PD. PMID: 16779671
    3. Cys-to-Ala mutations of PITP show that neither Cys95 nor Cys188 is essential for lipid transfer activity; however, chemical modification of Cys95 results in the loss of lipid transfer activity. PMID: 11478882
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    PtdIns transfer protein family, PI transfer class I subfamily
  • 组织特异性：
    Expressed in a wide range of tissues.
  • 数据库链接：

    KEGG: rno:29525

    STRING: 10116.ENSRNOP00000005368

    UniGene: Rn.9771