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  4. Recombinant Rat Protein NOV homolog (Nov)

Recombinant Rat Protein NOV homolog (Nov)

  • 中文名称：
    大鼠Nov重组蛋白
  • 货号：
    CSB-YP874147RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nov重组蛋白
  • 货号：
    CSB-EP874147RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nov重组蛋白
  • 货号：
    CSB-EP874147RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nov重组蛋白
  • 货号：
    CSB-BP874147RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nov重组蛋白
  • 货号：
    CSB-MP874147RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nov
  • Uniprot No.：
  • 别名：
    Ccn3; NovCCN family member 3; Cellular communication network factor 3; Nephroblastoma-overexpressed gene protein homolog; Protein NOV homolog; NovH
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-351
  • 氨基酸序列
    QVSATLRCP SRCPSQCPSI SPTCAPGVRS VLDGCSCCPV CARQRGESCS EMRPCDQSSG LYCDRSADPN NETGICMVPE GDNCVFDGVI YRNGEKFEPN CQYHCTCRDG QIGCVPRCQL DVLLPGPDCP APKKVAVPGE CCEKWTCGSE EKGTLGGLAL PAYRPEATVG VELSDSSINC IEQTTEWSAC SKSCGMGLST RVTNRNLQCE MVKQTRLCMV RPCEQEPGEA TDMKGKKCLR TKKSLKSIHL QFKNCTSLYT YKPRFCGICS DGRCCTPFNT KTIQVEFQCL PGQIIKKPVM VIGTCTCHSN CPQNNEAFLQ ELELKTSRGE M
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival. Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts. Involved in bone regeneration as a negative regulator. Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification. Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion. Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway. Contributes to the control and coordination of inflammatory processes in atherosclerosis. Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement.
  • 基因功能参考文献：
    1. CCN3 is expressed by articular chondrocytes in normal rat knees, whereas it is rapidly down-regulated in osteoarthritic knees. PMID: 27853940
    2. A novel, dual role of CCN3 in experimental glomerulonephritis: pro-angiogenic and antimesangioproliferative effects. PMID: 22538190
    3. Prenatal lead exposure decreased the NOV protein and mRNA expression in the hippocampus of offspring. PMID: 20635690
    4. Data show that CCN family protein 3 (CCN3) is abundantly produced in rat developing epiphyseal cartilage. PMID: 21871891
    5. These findings identify a new paracrine role of NOV in the development of cerebellar granule neurons. PMID: 19286457
    6. CCN3 suppresses neointimal thickening through the inhibition of vascular smooth cell migration and proliferation. PMID: 20139355
    7. Data show that RNA levels of cyr61 and Nov are upregulated in C6 cells transfected with connexin 43. PMID: 12064632
    8. NOV is expressed during liver fibrogenesis and HSCs may be an important source of hepatic NOV. PMID: 15345329

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  • 亚细胞定位：
    Secreted. Cytoplasm. Cell junction, gap junction.
  • 蛋白家族：
    CCN family
  • 组织特异性：
    Widely expressed. Highly expressed in neurons of dorsal root ganglia and dorsal horn of the spinal cord (at protein level). Expressed in astrocytes (at protein level). In cartilage, dominantly expressed in the chondrocyte territorial matrix.
  • 数据库链接：

    KEGG: rno:81526

    STRING: 10116.ENSRNOP00000011904

    UniGene: Rn.162955