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  4. Recombinant Rat Protein SET (Set)

Recombinant Rat Protein SET (Set)

  • 货号：
    CSB-YP730930RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730930RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730930RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730930RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730930RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Set
  • Uniprot No.：
  • 别名：
    Set; Ab1-115; Protein SET; Liver regeneration-related protein LRRGR00002; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-I
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-289
  • 氨基酸序列
    APKRQSAIL PQPKKPRPVA APKLEDKSAS PGLPKGEKEQ QEAIEHIDEV QNEIDRLNEQ ASEEILKVEQ KYNKLRQPFF QKRSELIAKI PNFWVTTFVN HPQVSALLGE EDEEALHYLT RVEVTEFEDI KSGYRIDFYF DENPYFENKV LSKEFHLNES GDPSSKSTEI KWKSGKDLTK RSSQTQNKAS RKRQHEEPES FFTWFTDHSD AGADELGEVI KDDIWPNPLQ YYLVPDMDDE EGEAEDDDDD DEEEEGLEDI DEEGDEDEGE EDDDEDEGEE GEEDEGEDD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.
  • 基因功能参考文献：
    1. results suggest that SET is part of a neuronal apoptotic pathway induced by an amyloid precursor protein cytoplasmic subdomain and related to Alzheimer's disease [SET] PMID: 16162853
    2. induced expression of the C-terminal fragment (I(2CTF)) of I(2)(PP2A), also called SET, in rat brain, decrease in protein phosphatase 2A (PP2A) activity, abnormal hyperphosphorylation of tau, and neurodegeneration PMID: 20651003
  • 亚细胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus, nucleoplasm.
  • 蛋白家族：
    Nucleosome assembly protein (NAP) family
  • 组织特异性：
    Widely expressed, with higher expression in brain, thymus, spleen and bone marrow, and lower expression in heart, liver and muscle.
  • 数据库链接：

    KEGG: rno:307947

    STRING: 10116.ENSRNOP00000039454

    UniGene: Rn.76937