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  4. Recombinant Rat Putative RNA-binding protein 3 (Rbm3)

Recombinant Rat Putative RNA-binding protein 3 (Rbm3)

  • 中文名称：
    大鼠Rbm3重组蛋白
  • 货号：
    CSB-YP849766RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rbm3重组蛋白
  • 货号：
    CSB-EP849766RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rbm3重组蛋白
  • 货号：
    CSB-EP849766RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rbm3重组蛋白
  • 货号：
    CSB-BP849766RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rbm3重组蛋白
  • 货号：
    CSB-MP849766RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rbm3
  • Uniprot No.：
  • 别名：
    Rbm3; RNA-binding protein 3; RNA-binding motif protein 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-155
  • 氨基酸序列
    MSSEEGKLFV GGLNFNTDEQ ALEDHFSSFG PISEVVVVKD RETQRSRGFG FITFTNPEHA SDVMRAMNGE SLDGRQIRVD HAGKSARGTR GGAFGAHGRG RSYSRGGGDQ GYGSGRYDSR PGGYGYGYGR SRDYSGSQGG YDRYSGGNYR DNYDN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation.
  • 基因功能参考文献：
    1. This study showed that a 1 degrees C reduction in temperature can induce pleiotropic biochemical changes by upregulating global protein synthesis in neurons. PMID: 26265550
    2. RBM3 expression was increased in astrocytes after spinal cord injury. RBM3 regulated proliferation of astrocytes in vitro. PMID: 24668366
    3. RBM3 might play important roles in central nervous system pathophysiology after spinal cord injury PMID: 24570111
    4. Aa cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass. RBM3, which was induced most highly in atrophic muscle from old rats, may be a therapeutic target to prevent muscle loss. PMID: 18753264
    5. These results indicate that expression of RBM3 is dynamically regulated in the developing brain and suggest that it contributes to translation-dependent processes underlying proliferation, differentiation, and plasticity. PMID: 19150436

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, dendrite. Note=Localizes in mRNA granules in dendrites. Isoform 1 shows a much higher dendritic localization than isoform 2.
  • 组织特异性：
    Widely expressed in the brain. Highly expressed in the cerebellum and olfactory bulb (at protein level). Expressed in neurons and glial cells.
  • 数据库链接：

    KEGG: rno:114488

    STRING: 10116.ENSRNOP00000007367

    UniGene: Rn.18057