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  4. Recombinant Rat RAS guanyl-releasing protein 4 (Rasgrp4)

Recombinant Rat RAS guanyl-releasing protein 4 (Rasgrp4)

  • 中文名称：
    大鼠Rasgrp4重组蛋白
  • 货号：
    CSB-YP848140RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rasgrp4重组蛋白
  • 货号：
    CSB-EP848140RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rasgrp4重组蛋白
  • 货号：
    CSB-EP848140RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rasgrp4重组蛋白
  • 货号：
    CSB-BP848140RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rasgrp4重组蛋白
  • 货号：
    CSB-MP848140RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rasgrp4RAS guanyl-releasing protein 4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-678
  • 氨基酸序列
    MNRKDIKRKS HQECSGKAGG HGRPRQARRH KTCPTPREIS KVMASLNLGV LSESSCSVDE LLEECIRCFD SAGSLHRGDH ILKMVLTMHS WVLPSSDLAA RLLTSYQKAA KDARELRQLQ ICYLVRYWLT HHPEVVHQEP QLEAIINRFW TTVAQEGNMA QRSLGDASNL LSPGGPGPPP LMSSPGLGKK RKVSLLFDHL ETEELAQHLT YLEFRSFQAI TPQDLRGYVL QGSVRGCPAL EGSVGLSNSV SRWVQVMVLS RPGPAQRAQV LDKFIRVAQR LRQMQNFNTL MAVTGGLCHS AISRLKDSHV HLSPDSTKAL LELTELLSSH NNYAYYRRTW ASCTDFRLPV LGVHLKDLVS LYEAHPDRLP DGRLHLPKLN SLYLRLQELA ALQRQHPPCS ANEDLLHLLT LSLDLFYTED EIYELSYARE PRCPKSLPLS PFKAPVVVEW AHGVTPKPDS ATLGQHVEQL VESVFKNYDP EGHGSISLED FEKLSANFPF ACHGLHPPPR HGSGSFSREE LTKYLLHASA ICSKLGLAFL HAFQEVTFRK PTFCHSCNGF VSTGPLWGVT KRGYRCQDCG LCCHRHCRDQ VRVECKKRPE TKGDPGPPGA PGPATPLPPT GCGSEEGLSY TLSPHLESGC HLHHAWTQTE SSHSSWEPEM VPCPAPVLPS KASSKSSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
  • 基因功能参考文献：
    1. RasGRP-4 is aberrantly expressed in fibroblast-like synoviocytes and helps regulate their growth. PMID: 25330932
    2. Cloning of Ras guanine nucleotide releasing protein 4, and evaluation of its expression in mast cells and their bone marrow progenitors. PMID: 12217396
    3. RasGRP4 regulates the expression of prostaglandin D2 in mast cell PMID: 12493770
  • 亚细胞定位：
    Cytoplasm. Cell membrane.
  • 蛋白家族：
    RASGRP family
  • 组织特异性：
    Expressed by mast cells and their progenitors (at protein level).
  • 数据库链接：

    KEGG: rno:170668

    STRING: 10116.ENSRNOP00000046440

    UniGene: Rn.213071