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  4. Recombinant Rat Regulator of G-protein signaling 4 (Rgs4)

Recombinant Rat Regulator of G-protein signaling 4 (Rgs4)

  • 货号：
    CSB-YP019656RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019656RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019656RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019656RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019656RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgs4
  • Uniprot No.：
  • 别名：
    Rgs4; Regulator of G-protein signaling 4; RGP4; RGS4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-205
  • 氨基酸序列
    MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR VSQEEVKKWA ESLENLINHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLTNP SSCGAEKQKG AKSSADCTSL VPQCA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
  • 基因功能参考文献：
    1. After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR PMID: 26119705
    2. Data suggest that RGS4 proteins play an important pathophysiological role in the development and expression of l-DOPA-induced dyskinesia PMID: 24969021
    3. partial agonism of the M2 muscarinic receptor is regulated by the RGS4-mediated inhibition of G-protein signalling PMID: 24421355
    4. Tra2beta regulates the expression of RGS4 gene and is induced by morphine. PMID: 23977258
    5. data demonstrate that RGS4 in the dorsal striatum attenuates amphetamine-induced ERK signaling and decreases the behavioral efficacy of acute amphetamine likely by limiting mGluR5 function PMID: 22193724
    6. The functional activity and protein binding partners of a candidate AP-1R sequence were determined for a novel FRA-2-repressed gene, Rgs4. PMID: 21367864
    7. A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription. PMID: 20630860
    8. RGS4 was up-regulated only when RGS2 was down-regulated in the striatum after intracerebroventricular injection of forskolin PMID: 12603835
    9. up-regulation of RGS4 expression may contribute to changes in pain signal processing that lead to the development of hyperalgesia, and further affect its modulation by morphine. PMID: 12604710
    10. RGS4 is expressed at high levels in C-fiber primary sensory neurons in the adult rat dorsal root ganglion (DRG) and sciatic nerve transection results in a substantial down regulation of this transcript. PMID: 14550772
    11. Amphetamine may disinhibit RGS4-sensitive guanine nucleotide-binding protein alpha-subunit i- and/or q-coupled signaling pathways and favor mechanisms that counterbalance D(1) receptor stimulation. PMID: 16539683
    12. These observations suggest that RGS4-dependent attenuation of interneuronal autoreceptor signaling is a major factor in the elevation of striatal acetylcholine release in Parkinson disease. PMID: 16699510
    13. Expression of RGS4 mRNA was not affected by the corticosterone injection, neither in the CA1 area nor in other hippocampal subregions. PMID: 17060050
    14. study revealed an important coupling of RGS4 to serotonin signaling in cortical neurons and provided a molecular and cellular mechanism underlying the potential involvement of RGS4 in the pathophysiology of schizophrenia. PMID: 17220354
    15. Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking. PMID: 17632279
    16. After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs4, it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling. PMID: 18207159

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  • 数据库链接：

    KEGG: rno:29480

    STRING: 10116.ENSRNOP00000003774

    UniGene: Rn.11065