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  4. Recombinant Rat Regulator of G-protein signaling 5 (Rgs5)

Recombinant Rat Regulator of G-protein signaling 5 (Rgs5)

  • 中文名称：
    大鼠Rgs5重组蛋白
  • 货号：
    CSB-YP019657RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rgs5重组蛋白
  • 货号：
    CSB-EP019657RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rgs5重组蛋白
  • 货号：
    CSB-EP019657RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rgs5重组蛋白
  • 货号：
    CSB-BP019657RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rgs5重组蛋白
  • 货号：
    CSB-MP019657RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rgs5
  • Uniprot No.：
  • 别名：
    Rgs5; Regulator of G-protein signaling 5; RGS5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-181
  • 氨基酸序列
    MCKGLAALPH SCLERAKEIK IKLGILLQKP DSAVDLVIPY NEKPEKPAKA HKPSLEEVLQ WRQSLDKLLQ SNYGFASFKS FLKSEFSEEN LEFWVACENY KKIKSPIKMA EKAKQIYEEF IQTEAPKEVN IDHFTKDITM KNLVEPSPHS FDLAQKRIYA LMEKDSLPRF VRSEFYKELI N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
  • 基因功能参考文献：
    1. AT1R activation results in translocation of RGS5 toward the plasma membrane, limiting AT1R-mediated vasoconstriction through its role in Gq/11 protein-dependent signaling. PMID: 29061726
    2. The enhancement of RGS5 activity by GPSM3 is maintained under these conditions. PMID: 25842189
    3. Rgs5 and Dlx1 represent novel molecular targets for the regulation of ductus arteriosus maturation and closure. PMID: 24489801
    4. RGS5 and VEGF coexpressed in the area of choroidal neovascularization, and RGS5 expressed later than VEGF. PMID: 21054999
    5. Results demonstrate that RGS5 expression is a critical mediator of both vascular smooth muscle contraction and potentially, arterial remodeling. PMID: 21593453
    6. Rgs5 and Notch3 are expressed in pericytes of developing and injured teeth and have roles along with vascular-derived stem cells during pulp healing PMID: 17939118
    7. After 2 days of aortic banding-induced hypertrophy, thoracic aorta lost expression of Rgs5, it returned to normal at 1 week and increased many fold at 28 days, indicating that RGS expression and function correlate with vascular remodeling. PMID: 18207159

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  • 亚细胞定位：
    Cytoplasm. Membrane.
  • 数据库链接：

    KEGG: rno:54294

    STRING: 10116.ENSRNOP00000003705

    UniGene: Rn.1150