Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Renin receptor (Atp6ap2), partial

Recombinant Rat Renin receptor (Atp6ap2), partial

  • 货号：
    CSB-YP721457RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP721457RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP721457RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP721457RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP721457RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Atp6ap2; Atp6ip2; Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor) [Cleaved into: Renin receptor extracellular fragment; Renin receptor cytoplasmic fragment]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (v-ATPase) and the acidification of the endo-lysosomal system. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission.
  • 基因功能参考文献：
    1. From the data the s assume that activation of (Pro) renin receptor (P)RR and V-ATPase may play an important role in tubulointerstitial fibrosis with possible involvement of interaction of V-ATPase B2 subunit and (P)RR. PMID: 27121029
    2. Renal PRR has a role in regulation of K(+) homeostasis through a local mechanism involving intrarenal renin-angiotensin-aldosterone system and coordinated regulation of membrane Na(+)- and K(+)-transporting proteins. PMID: 27440776
    3. Prorenin receptor may be involved in the regulation of renal function and high salt-induced disorders. PMID: 25555681
    4. Soluble prorenin receptor via beta-catenin enhances urine concentration capability as a target of liver X receptor. PMID: 26984496
    5. increased expression of placental (pro)renin receptor in pre-eclampsia rats. PMID: 25767135
    6. expressed in normal adrenal gland PMID: 25668351
    7. These findings suggest that increased (P)RR plays a role in the development of ischemic acute kidney injury mediating possibly through activation of a renin-angiotensin system-independent pathway. PMID: 24817138
    8. Report that (pro)renin receptor blockade attenuates lipopolysaccharide-induced acute lung injury. PMID: 25844689
    9. Pro)renin receptor and insulin resistance: possible roles of angiotensin II-dependent and -independent pathways. [review] PMID: 22684035
    10. Prorenin receptor expressing cell density is stimulated by high-fat diet in visceral adipose tissue. PMID: 21483231
    11. The (P)RR promoter is enriched with activating histone codes in the kidneys of spontaneously hypertensive rats. PMID: 21803797
    12. Upregulation of renin and soluble prorenin/renin receptor in the collecting ducts, especially in the renal medulla of Cyp1a1Ren2 transgenic rats, may explain elevated levels of kidney angiotensin II in angiotensin II-dependent malignant hypertension. PMID: 21068087
    13. (Pro)renin receptor is involved in the development and progression of kidney disease in diabetes by enhancing renal production of inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1ss. PMID: 19769609
    14. brain PRR is functional and plays a role in the neural control of cardiovascular functions PMID: 20689062
    15. Blockade of the (pro)renin receptor (P)RR with "handle-region" peptide (HRP) does not improve target organ damage in renovascular hypertensive rats. PMID: 18212268
    16. prorenin receptor is present in neurons within the brain and its activation by renin initiates the MAP kinase signalling pathway PMID: 18326551
    17. the (pro)renin receptor system has two functions, an angiotensin-independent function related to (P)RR-induced intracellular signalling and its downstream effects and increased catalytic activity of receptor-bound (pro)reniN--REVIEW PMID: 18376005
    18. prorenin at high concentration binds the prorenin/renin receptor on vascular smooth muscle cells and is activated leading to increased expression of PAI-1 PMID: 18664599
    19. blocking the prorenin receptor did not ameliorate renal injury PMID: 18756297
    20. renin/prorenin receptor played a regulatory role in mesangial cells proliferation and extracellular matrix accumulation PMID: 19174157

    显示更多

    收起更多

  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, dendritic spine membrane. Cell projection, axon. Endosome membrane.
  • 数据库链接：

    KEGG: rno:302526

    STRING: 10116.ENSRNOP00000005138

    UniGene: Rn.12944