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  4. Recombinant Rat Replication initiator 1 (Repin1)

Recombinant Rat Replication initiator 1 (Repin1)

  • 货号：
    CSB-YP019564RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP019564RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP019564RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP019564RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP019564RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Repin1
  • Uniprot No.：
  • 别名：
    Repin1; Replication initiator 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-548
  • 氨基酸序列
    MLERRCRGPT AMGPAHPWLF SGPSQESSQP NRGLRYQGKS VAQPGGPAPV KVHRCAHCRK RFPGWVALWL HTRRCQARLP LPCHECNQRF RHAPFLALHL QVHASAVPDL GFICHLCGHS FRGWVALVLH LRAHSASKRP ITCPECNKRF WRQKQLRAHL RRCQPPAPEA RPFICGNCGR SFAQWDQLVV HKRVHVAEAL EEAAAKALGP RPRGRPSVTA PRPGGDAVDR PFQCACCGKR FRHKPNLIAH RRVHTGERPH QCPECGKRFT NKPYLTSHRR IHTGEKPYPC TECGRRFRHK PNLLSHSKIH KRSEVSAQAA SHTGSHLIAA EPMAQPALGV PLGSLRTPAE APASLHSCTD CGRSFRLERF LRLHQRQHTG ERPFTCTECG KNFGKKTHLV AHSRVHSGER PFACEECGRR FSQGSHLAAH RRDHAPERPF VCPDCGKAFR HKPYLAAHRR IHTGEKPYVC PDCGKAFSQK SNLVSHRRIH TGERPYACPD CDRSFSQKSN LITHRKSHIR DGAFCCAICG QTFDDEDRLL MHQKKHDA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending.
  • 基因功能参考文献：
    1. Data on gene expression in epididymal/subcutaneous adipose tissue suggest that Repin1 is more highly expressed in a congenic rat model of metabolic syndrome; thus, Repin1 may affect development of facets of metabolic syndrome. PMID: 21701954
    2. findings show that glutamate receptor delta2 interacted directly with AP-4; results suggest a potential involvement of AP-4 in the trafficking of delta2 in the brain. PMID: 14572453
    3. The functional unknown gene, Repin1, may be a novel candidate gene for the development of facets of the metabolic syndrome. PMID: 17173329
    4. It is concluded that the triplet repeat expansion in 3'-UTR of Repin1 leads to metabolic disorders as found in hHTG and WOKW rats and that Repin1 could be a novel candidate gene in the development of metabolic disorders. PMID: 17173329
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: rno:445541

    STRING: 10116.ENSRNOP00000011032

    UniGene: Rn.204397