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  4. Recombinant Rat Reticulon-4 receptor (Rtn4r)

Recombinant Rat Reticulon-4 receptor (Rtn4r)

  • 中文名称：
    大鼠Rtn4r重组蛋白
  • 货号：
    CSB-YP859560RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Rtn4r重组蛋白
  • 货号：
    CSB-EP859560RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Rtn4r重组蛋白
  • 货号：
    CSB-EP859560RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Rtn4r重组蛋白
  • 货号：
    CSB-BP859560RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Rtn4r重组蛋白
  • 货号：
    CSB-MP859560RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rtn4r
  • Uniprot No.：
  • 别名：
    Rtn4r; Nogor; Reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-447
  • 氨基酸序列
    CPGA CVCYNEPKVT TSCPQQGLQA VPTGIPASSQ RIFLHGNRIS YVPAASFQSC RNLTILWLHS NALAGIDAAA FTGLTLLEQL DLSDNAQLRV VDPTTFRGLG HLHTLHLDRC GLQELGPGLF RGLAALQYLY LQDNNLQALP DNTFRDLGNL THLFLHGNRI PSVPEHAFRG LHSLDRLLLH QNHVARVHPH AFRDLGRLMT LYLFANNLSM LPAEVLVPLR SLQYLRLNDN PWVCDCRARP LWAWLQKFRG SSSEVPCNLP QRLAGRDLKR LAASDLEGCA VASGPFRPFQ TNQLTDEELL GLPKCCQPDA ADKASVLEPG RPASAGNALK GRVPPGDTPP GNGSGPRHIN DSPFGTLPGS AEPPLTALRP GGSEPPGLPT TGPRRRPGCS RKNRTRSHCR LGQAGSGSSG TGDAEGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development.
  • 基因功能参考文献：
    1. This study identifies a separation of functions for the NgR-regulated WNK1 in mediating proliferation, migration and axonal extension in PC12 cells. PMID: 28489665
    2. siRNA-mediated knockdown of NgR expression contributes to neurite outgrowth in vitro. PMID: 27033267
    3. These data suggest that increased Rtn4 receptor expression in the perilesional cortex may contribute to the impaired regeneration associated with Matrix metalloproteinases inhibition in the subacute phase of cerebral infarction PMID: 26945033
    4. There was a striking transient up-regulation of the NgR(1) protein and mRNA in both the rat hippocampus and cortex in response to CPR. PMID: 23158614
    5. The overexpression of Nogo-A and the activation of NgR inhibit neurite outgrowth and alter neuronal metabolism, resulting in overproduction and/or release of Abeta, which in turn may trigger the onset and development of AD. PMID: 22139298
    6. NgR shRNA knockdown reduced, but did not eliminate, the effects of oxygen-glucose deprivation in rat hippocampal slices in tissue culture PMID: 20337950
    7. these results suggest that NgR knockdown may promote central nervous system axonal regeneration and functional recovery after ischemic cerebral injury PMID: 20828545
    8. Mechanistic studies reveal that myelin oligodendrocyte glycoprotein (Mog) suppresses long-term potentiation in a Nogo receptor-1 (NgR1)-dependent manner. PMID: 20844138
    9. Increased NgR mRNA and NgR protein may be associated with the hypoxic-ischemic injury and may inhibit the neuron regeneration. PMID: 17294731
    10. Behavioral training interacts with the effects of the axonal growth promoter, NOGO extracellular peptide NEP 1-40/NgR1, and may accelerate behavioral recovery after focal cortical ischemia. PMID: 20075346
    11. Nogo-A in central nervous system (CNS) myelin prevents axonal regeneration through interaction with Nogo receptor 1 PMID: 19901030
    12. Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and Nogo-66 receptor antagonist peptide promotes axonal regeneration. PMID: 12037567
    13. Nogo66 receptor antibodies may represent a useful therapeutic approach for promoting CNS repair after injury. PMID: 15297463
    14. A soluble Nogo receptor differentially affects plasticity of spinally projecting axons. PMID: 15548200
    15. After 48 h in culture after siRNA-mediated knockdown of Rho-A, neurite outgrowth was enhanced by 30% compared to that after p75NTR and 50% after NgR silencing. PMID: 15737741
    16. Immunoelectron microscopic investigation clearly demonstrated that the Nogo-66 receptor immunoreactivity could be ascertained at the gap junction between glia cells. PMID: 16088223
    17. alterations in NgR expression were not observed following traumatic brain injury PMID: 16321384
    18. This study demonstrated with immunohistochemistry and immuno-electron microscopy abundant Nogo-66 receptor immunoreactive gap junctions between pituicytes. PMID: 16603920
    19. role for Nogo receptors (NgRs) in macrophage efflux from sites of inflammation in peripheral nerve PMID: 17329206
    20. Nogo receptor antagonizes p75NTR-dependent motor neuron death PMID: 18182498
    21. myelin protein and Nogo-66 promoted the differentiation of NPCs into glial lineage. NgR and mTOR-Stat3 pathway were involved in this process PMID: 18365011
    22. spatio-temporal expression pattern of NgR1, NgR2 & NgR3 mRNAs & corresponding proteins in developing olfactory system; data suggest, in non-pathological conditions, NgR1 & homologs may play a role in axon outgrowth in the olfactory system PMID: 19063867
    23. Inhibition of Nogo receptor by RNA interference enhances optic nerve regeneration. PMID: 19575706

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft. Cell projection, dendrite. Perikaryon. Cell projection, axon.
  • 蛋白家族：
    Nogo receptor family
  • 组织特异性：
    Detected in embryonic cerebellum, in spinal cord motor neurons and in dorsal root ganglia. Detected in adult brain, in neocortex, hippocampus, striatum, thalamus and dorsal root ganglion neurons (at protein level).
  • 数据库链接：

    KEGG: rno:113912

    STRING: 10116.ENSRNOP00000041517

    UniGene: Rn.229952