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  4. Recombinant Rat S-adenosylmethionine synthase isoform type-1 (Mat1a)

Recombinant Rat S-adenosylmethionine synthase isoform type-1 (Mat1a)

  • 中文名称：
    大鼠Mat1a重组蛋白
  • 货号：
    CSB-YP013516RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Mat1a重组蛋白
  • 货号：
    CSB-EP013516RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Mat1a重组蛋白
  • 货号：
    CSB-EP013516RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Mat1a重组蛋白
  • 货号：
    CSB-BP013516RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Mat1a重组蛋白
  • 货号：
    CSB-MP013516RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Mat1a
  • Uniprot No.：
  • 别名：
    Mat1a; Ams1S-adenosylmethionine synthase isoform type-1; AdoMet synthase 1; EC 2.5.1.6; Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-397
  • 氨基酸序列
    MNGPVDGLCD HSLSEEGAFM FTSESVGEGH PDKICDQISD AVLDAHLKQD PNAKVACETV CKTGMVLLCG EITSMAMIDY QRVVRDTIKH IGYDDSAKGF DFKTCNVLVA LEQQSPDIAQ CVHLDRNEED VGAGDQGLMF GYATDETEEC MPLTIVLAHK LNTRMADLRR SGVLPWLRPD SKTQVTVQYV QDNGAVIPVR VHTIVISVQH NEDITLEAMR EALKEQVIKA VVPAKYLDED TIYHLQPSGR FVIGGPQGDA GVTGRKIIVD TYGGWGAHGG GAFSGKDYTK VDRSAAYAAR WVAKSLVKAG LCRRVLVQVS YAIGVAEPLS ISIFTYGTSK KTERDELLEV VNKNFDLRPG VIVRDLDLKK PIYQKTACYG HFGRSEFPWE VPKKLVF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
  • 基因功能参考文献：
    1. The oncogene PDRG1 is an interaction target of methionine adenosyltransferases. PMID: 27548429
    2. Mat1a and Mthfr genes were downregulated, during early stages of rat 2-acetylaminofluorene-induced liver carcinogenesis. PMID: 22213190
    3. we found for the first time a post-transcriptional regulation of MAT1A and MAT2A by AUF1 and HuR in hepatocellular carcinoma. PMID: 22318685
    4. Data support a role for AUF1 and HuR/methyl-HuR in liver de-differentiation and development through the posttranslational regulation of MAT1A and MAT2A mRNAs. PMID: 20102719
    5. role of an intrasubunit disulfide in the association state; residues involved in this disulfide have been identified by mass spectrometry and using a set of single cysteine mutants as cysteines 35 and 61 PMID: 12496263
    6. methionine adenosyltransferase complexes by a catalytic mechanism that relies on Lys182 in the correct positioning of the substrates PMID: 12888348
    7. In this work, methionine adenosyltransferase I/III was identified in most rat tissues, both in the cytoplasm and the nucleus. PMID: 19497982

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  • 蛋白家族：
    AdoMet synthase family
  • 组织特异性：
    Detected in liver (at protein level). Expressed in liver.
  • 数据库链接：

    KEGG: rno:25331

    STRING: 10116.ENSRNOP00000015190

    UniGene: Rn.10418