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  4. Recombinant Rat Semaphorin-3A (Sema3a)

Recombinant Rat Semaphorin-3A (Sema3a)

In Stock
  • 货号：
    CSB-EP717391RA
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Sema3a
  • Uniprot No.：
  • 别名：
    Sema3a; Semaphorin-3A; Semaphorin III; Sema III
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    90.6kDa
  • 表达区域：
    21-772aa
  • 氨基酸序列
    NYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEVLLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGHSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRVGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKTKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in guiding growing axons towards their targets by forming a molecular boundary that instructs axons to engage in the formation of specific nerve tracts. Binds to neuropilin. Involved in the development of the olfactory system and in neuronal control of puberty.
  • 基因功能参考文献：
    1. decreased expression of Sema3A in bone mesenchymal stem cells from type 2 diabetes mellitus rats compared with bone mesenchymal stem cells from normal rats. PMID: 29774455
    2. decreased expression of Sema3A/Nrp1 was observed in periapical lesions and is potentially involved in the bone resorption of the periapical area, suggesting that Sema3A/Nrp1 may contribute to the pathological development of apical periodontitis PMID: 29457037
    3. describe methods to visualize endocytosed Semaphorin3A (Sema3A) molecules and to characterize the rate and pathway of internalization in primary rat neuronal cultures using semiconductor quantum dot nanoparticles PMID: 27787858
    4. describe microfabrication and substrate stripe micropatterning of Sema3A PMID: 27787862
    5. a Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic neurons during the period of naturally occurring cell death during development of the peripheral nervous system. PMID: 27143756
    6. Data suggest that voltage-gated calcium and sodium channels mediate Sema3A retrograde signaling that regulates dendritic GluA2 localization and branch formation. PMID: 26638837
    7. Semaphorin 3A deficiency could improve hypoxia-induced myocardial injury via resisting inflammatory factors secretion, viability decline, cardiomyocyte apoptosis, reactive oxygen species release, ATP generation decline. PMID: 26950444
    8. Upregulation of Sema3A increased cardiac electrical stability and reduced ventricular arrhythmias (VA). Sema3A silencing lead to sympathetic hyperinnervation, increased myocardial norepinephrine content and inducible VAs. PMID: 26787044
    9. Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections. PMID: 25161316
    10. This study delineate a Semaphorin-dependent signaling pathway that promotes dendritic complexity via the actin regulatory protein Farp1. PMID: 24899721
    11. Overexpression of Sema3a in myocardial infarction border zone could reduce the inducibility of ventricular arrhythmias by reducing sympathetic hyper-reinnervation after infarction. PMID: 23711091
    12. Sema3A binding to CS-E in the PNNs may be a mechanism whereby PNNs restrict growth and plasticity and may represent a possible point of intervention to facilitate neuronal plasticity. PMID: 23940048
    13. In the early stages of O2-induced retinopathy, retinal microglia are activated to produce IL-1beta, which sustains the activation of microglia and induces microvascular injury through the release of Sema3A from adjacent neurons. PMID: 23766263
    14. Interplay of neuropilin-1 and semaphorin 3A after partial hepatectomy in rats. PMID: 23049211
    15. These new data on Class 3 Semaphorins and their receptors provide more information about the complex reactive events that occur bilaterally in the retino-collicular system following unilateral adult optic nerve injury. PMID: 23139269
    16. Cytoskeleton reorganization mediated by Sema3A is relatively slow to induce filopodia repulsion at the growth cone. PMID: 22997549
    17. Sema3a was expressed in the heart by cardiocytes. Increased expression of sema3a may partly account for sympathetic denervation in congestive heart failure. PMID: 21933622
    18. Sema3A regulates the earliest step of neuronal morphogenesis by polarizing axon/dendrite formation. PMID: 21835341
    19. These data are consistent with a model whereby Sema3A and 3F, in combination with other guidance molecules, contributes to the navigation of DA axons to their final synaptic targets. PMID: 20298787
    20. the expression of Sema3A is increased markedly in basal cells of the newly healed corneal epithelium, and this up-regulation of Sema3A is not associated with cell proliferation. PMID: 20331965
    21. NRP2 is necessary to trigger Sema3A-induced glioma cell repulsion and attraction. PMID: 19855168
    22. Sema3A-induced growth cone collapse of DRG neurons was suppressed by expression of Fes-negative mutants. Fes links Sema3A signals to CRMP-CRAM, and that NP-1 negatively regulates PlexA1 activation by Fes in resting condition. PMID: 12093729
    23. SEMA3 may havea role in modulating the cell fate of axotomized retinal ganglion cells PMID: 12376549
    24. Sema3A regulates the migration of GABAergic neurons in the developing neocortex PMID: 12454988
    25. The expression profile of Sema3A mRNA and the axonal growth-associated protein GAP-43 mRNA during the process of electrically induced epileptogenesis in rats was investigated PMID: 12821384
    26. These results suggest that Sema3A is regulated differently in spinal motoneurons and brain neurons following axonal injury. PMID: 14727128
    27. We investigated the ability of semaphorin3A to selectively reduce NGF-induced sprouting and neuropathic pain in adult rats. Mature sensory afferents maintain their responsiveness to semaphorin3A suggesting it might be used therapeutically PMID: 14749426
    28. The data of this study imply that Sema3A acts as a short-range repellent that regulates the timing of target contact by trigeminal axons. PMID: 14755522
    29. Semaphorin3A mRNA and protein are up-regulated in the scar and in motoneurons from 3 days and upto 3 weeks after injury. PMID: 15094469
    30. association with proteoglycans in the extracellular matrix of neuronal cells plays an important role in the localization of the chemorepulsive guidance cue Sema3A, and that this interaction may enhance its biological activity PMID: 15866045
    31. The chemorepulsion studies are consistent with a role for Sema3A, not Sema3F, in restricting geniculate axons from the epithelium until E17, when axons penetrate the epithelium. PMID: 16217616
    32. novel semaphorin-mediated mechanism of neuroprotection whereby stressed neurons can protect themselves from further damage by activated microglia. PMID: 16467521
    33. Expression of Sema3A by Schwann cells not only suppresses nerve terminal plasticity at specific neuromuscular synapses, but may also contribute to their early and selective loss in the motor neuron disease ALS. PMID: 16677822
    34. We suggest that cell invasion, semaphorin 3A and neuropilin-1 induction, and disruption of the internal organization of the optic nerve contribute to axotomy-induced degenerative processes. PMID: 16906543
    35. Sema3A enhanced axon growth PMID: 18041777
    36. From this study suggested Sema3A may function as a chemoattractive guidance signal for the radial migration of newborn cortical neurons toward upper layers. PMID: 18059265
    37. Semaphorin3A was up-regulated and reached its peak at two time points: 24 hours and 14 days after surgery in retinal detachment model PMID: 18815803
    38. Data highlight an active role for satellite cells as a source of Semaphorin 3A expression triggered by HGF, suggesting that regenerative activity may reside in satellite cells and could play a role during postnatal myogenesis. PMID: 19515904

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Semaphorin family
  • 组织特异性：
    Expressed in the dorsal root ganglia.
  • 数据库链接：

    KEGG: rno:29751

    STRING: 10116.ENSRNOP00000036472

    UniGene: Rn.44410