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  4. Recombinant Rat Sigma non-opioid intracellular receptor 1 (Sigmar1), partial

Recombinant Rat Sigma non-opioid intracellular receptor 1 (Sigmar1), partial

  • 中文名称：
    大鼠Sigmar1重组蛋白
  • 货号：
    CSB-YP021320RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Sigmar1重组蛋白
  • 货号：
    CSB-EP021320RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Sigmar1重组蛋白
  • 货号：
    CSB-EP021320RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Sigmar1重组蛋白
  • 货号：
    CSB-BP021320RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Sigmar1重组蛋白
  • 货号：
    CSB-MP021320RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Sigmar1; Oprs1; Sigma non-opioid intracellular receptor 1; Sigma 1-type opioid receptor; Sigma1-receptor; Sigma1R
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112.
  • 基因功能参考文献：
    1. These results led us to hypothesize the existence of functional D2-sigma1R complexes on the rat striatal DA and glutamate nerve terminals and functional D2-sigma1R-DA transporter complexes on the striatal DA terminals. PMID: 28923416
    2. these results indicate that Sigmar1-dependent activation of IRE1alpha-XBP1s ER-stress response pathways are associated with inhibition of CHOP expression and suppression of cellular toxicity. PMID: 28667101
    3. Study showed that sigma1 receptors play a role in regulation of both CA1 synaptic efficacy and neural plasticity-dependent rat spatial learning ability. Its regulatory role in activity-dependent CA1-LTP is locality- and age-dependent, whereas its role in spatial learning ability is age-dependent. PMID: 26860755
    4. Study demonstrated that SKF10047 (SKF) of higher dosages (30-100 muM), suppress AMPAR-mediated responses of rat ON retinal ganglion cells via sigmaR1. SKF did not affect glutamate release from bipolar cells, suggesting that both the effects are a consequence of postsynaptic actions of SKF on retinal ganglion cells. PMID: 27373906
    5. Sigma-1 receptor was also upregulated in vivo upon VP16-CREB expression in astrocytes. PMID: 27761593
    6. acupoint catgut embedding exhibited antihyperalgesic effects via the inhibition of the Sig-1R that modulated p38 MAPK, but not ERK, expression in the complete Freund's adjuvant-induced inflammatory pain model in rats PMID: 28682953
    7. Together these results support the hypothesis that sigma1R agonists promote dissociation of sigma1R multimers into monomers, which then interact with DAT to stabilize an outward-facing DAT conformation and enhance cocaine binding. PMID: 28495886
    8. Study found: sigma-1 receptor is abundant in dorsal root ganglion (DRG) neuronal soma, but not in satellite cells; sigma-1 receptor is absent in processes of DRG neurons; in DRG neurons, S1R targets endoplasmic reticulum, nuclear envelope, and plasma membrane. PMID: 27339730
    9. data demonstrate that miR-297 promotes cardiomyocyte hypertrophy by inhibiting the expression of Sig-1R and activation of ER stress signaling, which provides a novel interpretation for cardiac hypertrophy. PMID: 28286226
    10. Study found that repeated treatment with oxaliplatin or paclitaxel causes neuropathy accompanied by the reduction of Sig-1Rs in the rat spinal cord PMID: 26234785
    11. Sigma-1 receptor blockade reduces the propensity to both acquire alcohol drinking and to seek alcohol. Data suggest that Sig-1R antagonists may have therapeutic potential in multiple stages of alcohol addiction. PMID: 25848705
    12. Cholinergic lesioning causes an increase of sigma-1 receptor expression in a small cortical area which may be neuroprotective. PMID: 25273321
    13. SKF83959 promoted the binding of DHEA with sigma-1 receptors in rat hippocampal microglia. PMID: 26031312
    14. Suggest that activation at the sigma-1 receptor chaperone may be involved in the action of some selective serotonin re-uptake inhibitors. PMID: 24508523
    15. data show that sigma1R is present in both sensory neurons and satellite cells in rat DRGs. PMID: 24015960
    16. sigma1R is downregulated following PO-induced endothelial injury in OVX rats. PMID: 23965801
    17. Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats. PMID: 23732704
    18. this study was designed to determine whether the role of sigma Receptors in cognitive function, anxiety, depression, and the regulation of stress responses extends to ethanol-seeking behavior PMID: 22878224
    19. Sig-1Rs negatively regulate the activity of GalCer synthesis under physiological conditions by enhancing the degradation of CGalT. PMID: 23105111
    20. sigma-1 receptor activation inhibits glutamate release from rat cortical nerve terminals. PMID: 22357973
    21. sigmaR1 may be involved in the regulation of output signaling of ganglion cells by preferentially modulating NMDA receptor-mediated excitatory postsynaptic currents of these retinal neurons. PMID: 21555866
    22. Acute withdrawal from chronic intermittent ethanol exposure triggered sigma-1 receptors that act to depress the efficacy of excitatory inputs in triggering action potentials during long term potentiation. PMID: 21314692
    23. These data further confirmed that Sig-1Rs play critical roles in the central nervous system PMID: 21905129
    24. Activation of sigma-receptors plays a key facilitatory role in the reinforcing effects of alcohol through a potential mechanism that contributes to binge-like and excessive drinking. PMID: 21346735
    25. results suggest that sigma-1 receptors may amplify the D1 receptor agonist-induced PKA activation by sigma-1 receptors PMID: 20732358
    26. sigmaR1 may have neuromodulatory and neuroprotective roles in the retina. PMID: 20223280
    27. Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates hypertension-induced kidney hypertrophy in ovariectomized rats PMID: 20404054
    28. Sig-1Rs as endogenous regulators of hippopcampal dendritic spine formation suggest a free radical-sensitive ER-mitochondrion-Rac1.GTP pathway in the regulation of dendritic spine formation in the hippocampus PMID: 20018732
    29. Results suggest that sigma receptors serve as auxiliary subunits to voltage-gated K+ channels with distinct functional interactions, depending on the presence or absence of ligand. PMID: 11988171
    30. Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. PMID: 12037190
    31. Sigma-1 receptors play an important role in nerve growth factor-induced neurite sprouting in vitro. PMID: 12438547
    32. Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system. Sigma(1)-receptor colocalized with specific markers of progenitor (A2B5) and mature oligodendrocytes (GalC, RIP). PMID: 12535781
    33. The Double immunofluorescence studies showed that sigma(1)-receptor co-localized with S100 protein, a specific marker of Schwann cells, in both rat sciatic nerve Schwann cells and Schwann cells in cultures. PMID: 15064136
    34. Sigma-1 receptors may play an important role in directing epidermal growth factor (EGF)signaling towards neuritogenesis, perhaps by shifting EGF receptors from the lipid raft into non-raft regions. PMID: 15170821
    35. Sig-1Rs targeting GalCer-containing lipid microdomains are important for oligodendrocyte differentiation. PMID: 15466698
    36. Sig-1R plays an important role in BDNF signaling leading to glutamate release as shown by antidepressant pretreatment PMID: 16522641
    37. role of opioid receptor sigma 1 modulating sensitivity to morphine in the periaqueductal gray, the rostroventral medulla, and the locus coeruleus of the rat PMID: 17545312
    38. Demonstrate that N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine protects liver against the deleterious effects of ischemia-reperfusion and suggest that sigma(1) receptors play an important role in the protective effect. PMID: 17964567
    39. sigma-1 receptor activation can regulate calcium homeostasis and signaling in RGCs, likely by directly influencing the activity of L-type voltage-gated calcium channels. PMID: 18641291
    40. sigma-1 receptor stimulation inhibits ASIC1a-mediated membrane currents and consequent intracellular Ca2+ accumulation. PMID: 18723775
    41. The results collectively support an endogenous role for brain Sig-1Rs in the modulation of excessive ethanol intake and reinforcement. PMID: 18946467
    42. N,N-dimethyltryptamine is an endogenous agonist for the sigma-1 receptor PMID: 19213917

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  • 亚细胞定位：
    Nucleus inner membrane. Nucleus outer membrane. Nucleus envelope. Cytoplasmic vesicle. Endoplasmic reticulum membrane. Membrane; Single-pass membrane protein. Lipid droplet. Cell junction. Cell membrane. Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族：
    ERG2 family
  • 组织特异性：
    Expressed in ependymocytes and neurons throughout the CNS from the olfactory bulb to the spinal cord. Expressed by progenitor, mature and satellite oligodendrocytes and by Schwann cells (at protein level). Expressed in liver, intestine, kidney, brain, lun
  • 数据库链接：

    KEGG: rno:29336

    STRING: 10116.ENSRNOP00000019795

    UniGene: Rn.1129