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  4. Recombinant Rat Signal transducer and activator of transcription 5A (Stat5a)

Recombinant Rat Signal transducer and activator of transcription 5A (Stat5a)

  • 货号：
    CSB-YP022814RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022814RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022814RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022814RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022814RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Stat5a; Mgf; Signal transducer and activator of transcription 5A; Mammary gland factor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-793
  • 氨基酸序列
    MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRGQATQL LEGLVQELQK KAEHQVGEDG FVLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNCSSPA GVLVDAMSQK HLQINQTFEE LRLITQDTES ELKKLQQTQE YFIIQYQESL RIQAQFGQLA QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELV EKHQKTLQLL RKQQTIILDD ELIQWKRGQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNR RSNHLEDYNS MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRD FSIRSLADRL GDLNYLIYVF PDRPKDEVFA KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGANATYM DQAPSPVVCP QAHYNMYPPN PDPVLDQDGE FDLDETMDVA RHVEELLRRP MDSLDPRLSP PAGLFTSARS SLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Carries out a dual signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
  • 基因功能参考文献：
    1. found that phosphorylated STAT5 was expressed in almost all oxytocin neurones of late-pregnant and lactating rats but was almost absent from oxytocin neurones of virgin rats. PMID: 26670189
    2. STAT3/miR-211/STAT5A signaling plays a key role in mesenchymal stem cell migration. PMID: 27145179
    3. Findings define a novel molecular mechanism for Jak2/Stat5 mediated Suppressor of cytokine signalling-6 (SOCS6) signalling. PMID: 22125600
    4. Data show that STAT5 responsiveness to prolactin is enhanced by reproductive experience in multiple hypothalamic regions. PMID: 21363933
    5. Nuclear translocation of STAT5 can be used as a marker of prolactin receptor activation in hypothalamic dopaminergic neurons PMID: 11406124
    6. the 3'-UTR element reduced GH activation of a CYP2C12-luciferase construct harboring the 5'-Stat5 elements and speculate that binding of Stat5beta to the 3'-UTR element could be of relevance for the GH-dependent and sex-specific expression of CYP2C12. PMID: 12089354
    7. Activated Stat5a has a role in mammary gland cancer development in the rat and human. PMID: 15609129
    8. Results suggest that prolactin targets neurones of the supraoptic nucleus, influencing both activation of the JAK-STAT signalling pathway and neuronal excitability. PMID: 15855883
    9. Vitamin A-deficient diet results in serine-phosphorylated STAT5 accumulation in the liver. PMID: 15963505
    10. A significant increase in phosphorylated STAT5 was detected in the arcuate nucleus of female rats compared with same-sex controls after prolactin treatment PMID: 16110263
    11. STAT5A is modified with O-GlcNAc but is not Tyr-phosphorylated in hairless rats PMID: 16227201
    12. during lactation, STAT5 signaling is reduced and CIS is upregulated in tuberoinfundibular dopaminergic neurons PMID: 16357045
    13. Here we report for the first time that systemic treatment with leptin (5 mg/kg; intraperitoneal injection) also increased the number of nuclear STAT5 signals in the hypothalamus. PMID: 17353091
    14. STAT2/5a/5b/6 were confirmed to be significantly modulated during focal cerebral ischaemia. PMID: 17880360
    15. ICA512 is a regulator of cyclins D and beta-cell proliferation through STAT3 and STAT5 PMID: 18178618
    16. Methylprednisolone upregulates the expression of bcl-XL via a direct binding of the GR/STAT5 complex on the putative STAT5-binding site. PMID: 19228956
    17. analysis of in vivo binding of STAT5 to growth hormone-regulated genes PMID: 19423653

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Transcription factor STAT family
  • 组织特异性：
    Expressed in heart, lung, and weakly in muscle.
  • 数据库链接：

    KEGG: rno:24918

    STRING: 10116.ENSRNOP00000026662

    UniGene: Rn.154399