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  4. Recombinant Rat Sodium-dependent phosphate transporter 1 (Slc20a1), partial

Recombinant Rat Sodium-dependent phosphate transporter 1 (Slc20a1), partial

  • 中文名称：
    大鼠Slc20a1重组蛋白
  • 货号：
    CSB-YP888327RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc20a1重组蛋白
  • 货号：
    CSB-EP888327RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc20a1重组蛋白
  • 货号：
    CSB-EP888327RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc20a1重组蛋白
  • 货号：
    CSB-BP888327RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc20a1重组蛋白
  • 货号：
    CSB-MP888327RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc20a1
  • Uniprot No.：
  • 别名：
    Slc20a1; Pit1; Sodium-dependent phosphate transporter 1; Phosphate transporter 1; PiT-1; RPHO-1; Solute carrier family 20 member 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification.
  • 基因功能参考文献：
    1. mechanism involving TRPM7 and Pit-1 underpins the magnesium-mediated reversal of high-phosphate-associated vascular calcification PMID: 28123180
    2. Apelin ameliorates VC by suppressing osteoblastic differentiation of VSMCs through downregulation of Pit-1. PMID: 26581047
    3. NaPi-III mRNA expression is affected by hyperphosphatemia. PMID: 26782594
    4. Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1. PMID: 21643723
    5. Dexamethasone and cyclic AMP regulate sodium phosphate cotransporter (NaPi-IIb and Pit-1) mRNA and phosphate uptake in rat alveolar type II epithelial cells. PMID: 19806400
    6. phosphate uptake through the type III sodium-dependent phosphate cotransporter, Pit-1, leads to induction of apoptosis and subsequent calcification of VSMC. PMID: 19655218
    7. Sodium-phosphate cotransporter (PiT-1) soleus and red gastrocnemius was similar and seven- to eightfold greater than PiT-1 expression in white gastrocnemius. PiT-1 expression did not match pattern of P(i) uptake across fiber types. PMID: 14985238
    8. PiT-1 and PiT-2 were detected at the basolateral membrane of hepatocytes. PMID: 15564340
    9. Osteoblast autonomous Pi regulation via PiT-1 plays a role in bone mineralization. PMID: 17438129
    10. Phosphate uptake via Pit-1 is required for osteochondrogenic phenotypic change and calcification of vascular smooth muscle cells in vitro.[review] PMID: 17565274
    11. Pi transport across the plasma membrane does not correlate directly with calcification, but the expression of Pit-1 in the ER opens new possibilities for the study of the pathogenesis of vascular calcification. PMID: 19506901

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inorganic phosphate transporter (PiT) (TC 2.A.20) family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    KEGG: rno:81826

    STRING: 10116.ENSRNOP00000025294

    UniGene: Rn.162702