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  4. Recombinant Rat Solute carrier family 23 member 1 (Slc23a1), partial

Recombinant Rat Solute carrier family 23 member 1 (Slc23a1), partial

  • 中文名称：
    大鼠Slc23a1重组蛋白
  • 货号：
    CSB-YP895740RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc23a1重组蛋白
  • 货号：
    CSB-EP895740RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc23a1重组蛋白
  • 货号：
    CSB-EP895740RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc23a1重组蛋白
  • 货号：
    CSB-BP895740RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc23a1重组蛋白
  • 货号：
    CSB-MP895740RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc23a1
  • Uniprot No.：
  • 别名：
    Slc23a1; Svct1; Solute carrier family 23 member 1; Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
  • 基因功能参考文献：
    1. metabolic/oxidative stress in the liver induce different responses in the expression of ascorbic acid transporters SVCT1 and SVCT2 in intrahepatic and extrahepatic tissues, which may affect the overall bioavailability and cellular uptake of this vitamin PMID: 23708151
    2. glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells. PMID: 22348976
    3. In adult rats, when obstructive cholestasis was maintained for 8 weeks, a significant up-regulation of Slc23a2 accompanied by a down-regulation of Slc23a1 was found. PMID: 21733302
    4. inhibited by flavonoids, an intestinal transporter for vitamin c PMID: 11834736
    5. SVCT1 declines 45% with age PMID: 12559983
    6. SVCT1 immunoreactivity was observed in the brush border of proximal straight tubules in the medullary ray of renal cortex and the outer stripe of outer medulla, while SVCT2 was not localized in any region of the kidney. PMID: 16673096

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Xanthine/uracil permease family, Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily
  • 组织特异性：
    Highly expressed in the straight segment of proximal tubules in the kidney, in intestine and liver. Detected in epithelial cells of the bronchiole and epididymis.
  • 数据库链接：

    KEGG: rno:50621

    STRING: 10116.ENSRNOP00000027048

    UniGene: Rn.144579