Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Solute carrier family 40 member 1 (Slc40a1), partial

Recombinant Rat Solute carrier family 40 member 1 (Slc40a1), partial

  • 中文名称：
    大鼠Slc40a1重组蛋白
  • 货号：
    CSB-YP852868RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slc40a1重组蛋白
  • 货号：
    CSB-EP852868RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slc40a1重组蛋白
  • 货号：
    CSB-EP852868RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slc40a1重组蛋白
  • 货号：
    CSB-BP852868RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slc40a1重组蛋白
  • 货号：
    CSB-MP852868RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc40a1
  • Uniprot No.：
  • 别名：
    Slc40a1; Fpn1; Fpt1; Solute carrier family 40 member 1; CAR1; Cell adhesion regulator; Ferroportin-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major iron transporter that plays a key role in balancing cellular and systemic iron levels. Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes. When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma.
  • 基因功能参考文献：
    1. Data suggest that expression of ferroportin in intestinal mucosa can be regulated by dietary factors; here, partially hydrolyzed guar gum up-regulates expression of ferroportin in cecum mucosa in growing rats being treated for iron deficiency anemia with this probiotic; intestinal absorption of dietary iron appears to be up-regulated, as well. PMID: 28273797
    2. The significantly increased FPN1 level in small intestine facilitates digestive iron absorption, which maintains the serum iron concentration at a near-normal level to meet the increase of iron requirements PMID: 26788496
    3. In ischemic rats, Fpn1 expression in the cerebral cortex and hippocampus was decreased. PMID: 19766498
    4. Data suggest that expression of ferroportin (Slc40a1) in intestinal mucosa can be regulated by dietary factors; here, expression of ferroportin in mucosa of duodenum is down-regulated by prebiotic supplement, oligofructose, in iron-deficiency anemia. PMID: 25745840
    5. Atp7a knockdown in IEC-6 cells enhanced transepithelial iron flux via a novel molecular mechanism involving transcriptional induction of Fpn1 gene expression. PMID: 24174620
    6. The role for intracellular hepcidin generated in the substantia nigra is particularly relevant to restrict iron release by down-regulation FPN1 expression PMID: 22659129
    7. Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver. PMID: 22469696
    8. Decreased intracellular levels of iron in preneoplastic foci might be attributed to increased iron export from the cells, driven by upregulation of ferroportin (Fpn1. PMID: 21785164
    9. Iron absorption during suckling is largely refractory to changes in expression of the systemic iron regulator hepcidin, and this in turn reflects limited expression of Fpn1 protein in the small intestine. PMID: 21570398
    10. With the increases of iron levels in diet, the levels of serum iron, serum ferretin, and transferrin saturation were gradually increased, and the expression of ferroprotin mRNA expression level in duodenum was decreased. PMID: 18839536
    11. contributes to iron accumulation in a cell model of Parkinson's disease PMID: 19913091
    12. the finding of a novel mutation (V162del) in ferroportin1 in an Australian family with autosomal dominant hemochromatosis; the mutation disrupts the function of the ferroportin1 protein, leading to impaired iron homeostasis and iron overload PMID: 12091366
    13. direct evidence for the existence of ferroportin1 protein in the rat brain. age has a significant effect on the expression of ferroportin1 protein in the cortex, hippocampus, striatum and substantia nigra of the rat brain. PMID: 12401946
    14. Ferroportin may function as a modulator of DMT1 activity and play a role in Fe(III) uptake, possibly by affecting the number or affinity of citrate binding sites. PMID: 15114483
    15. Ferroprotin-1 gene expression is up-regulated by treatment with the pro-inflammatory cytokine IL-1beta in rat C6 cells, taken as a glial cellular model. PMID: 15172111
    16. Findings suggest that ferroportin may transport iron into the mucous granule where it would be lost during discharge of mucous. PMID: 15944915
    17. Ferroportin 1 might have a role in heart iron homeostasis. PMID: 17383861
    18. FPN1 was decreased in normal peritoneal exudate macrophages after treatment with rHuEpo in vitro; hepcidin may play a major, causative role in the change of FPN1 synthesis PMID: 18189270

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ferroportin (FP) (TC 2.A.100) family, SLC40A subfamily
  • 数据库链接：

    KEGG: rno:170840

    STRING: 10116.ENSRNOP00000005228

    UniGene: Rn.15324