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  4. Recombinant Rat Solute carrier organic anion transporter family member 1A1 (Slco1a1), partial

Recombinant Rat Solute carrier organic anion transporter family member 1A1 (Slco1a1), partial

  • 货号：
    CSB-YP344400RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP344400RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP344400RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP344400RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP344400RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slco1a1
  • Uniprot No.：
  • 别名：
    OATP-1; Organic anion-transporting polypeptide 1; Slco1a1; SO1A1_RAT; Sodium-independent organic anion transporter 1; Solute carrier family 21 member 1; Solute carrier organic anion transporter family member 1A1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the Na(+)-independent transport of organic anions such as bromosulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids.
  • 基因功能参考文献：
    1. Oatp1a1 has a role in acute liver congestion as seen in gadoxetate disodium-enhanced MRI PMID: 25581836
    2. Oatp1a1 and Oatp2b1 expression levels are decreased by intestinal ischemia reperfusion. PMID: 24393554
    3. Although PDZK1 binding is required for optimal cell surface expression of oatp1a1, phosphorylation provides a mechanism for fast regulation of the distribution of oatp1a1 between the cell surface and intracellular vesicular pools. PMID: 21183661
    4. Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2. PMID: 11981753
    5. results suggest that urinary E(2)-17betaG excretion is subject to hormonal regulation and that the large gender difference can be explained by regulation in Oatp1-mediated reabsorption PMID: 12006354
    6. results demonstrate that both membrane targeting and functional activity of organic anion transporter 1 are controlled by the extent of N-glycosylation PMID: 12702494
    7. Oatp1-mediated uptake of trihydroxy bile acids taurocholate and glycocholate was four-to eightfold below that of corresponding dihydroxy conjugates. PMID: 12842829
    8. TNF-alpha represents the master cytokine responsible for HNF1-dependent down-regulation of Ntcp, Oatp1, and Oatp2 in CCl(4)-induced toxic liver injury. PMID: 12883478
    9. The lower OAT1 expression is responsible for the diminished secreted load of this organic anion in chronic renal failure. PMID: 15878738
    10. oligomerization of Oatp1a1 with PDZK1 is critical for its proper subcellular localization and function PMID: 15994332
    11. These findings identify the site of oatp1a1 phosphorylation and demonstrate that it is an ordered process, in which phosphorylation at S634 precedes that at S635. PMID: 16519530
    12. Show TNF-alpha dependent loss of Oatp1 during obstructive cholestatis. PMID: 17845533
    13. this is the first report suggesting that HGF regulates Oatp1 protein level and that the ameliorative effects of HGF in cholestasis was induced, at least in part, by correcting the down-regulation of the Oatp1 protein level PMID: 18031729
    14. Topology and glycosylation of rat hepatocyte Oatp1a1 was examined. PMID: 18308854
    15. Insights of this protein in kidneyin its cellular localization and response during ischemic acute kidney injury and recovery from it. PMID: 18922885

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  • 亚细胞定位：
    Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 组织特异性：
    Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon.
  • 数据库链接：

    KEGG: rno:50572

    STRING: 10116.ENSRNOP00000040752

    UniGene: Rn.231253