Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Solute carrier organic anion transporter family member 1A4 (Slco1a4), partial

Recombinant Rat Solute carrier organic anion transporter family member 1A4 (Slco1a4), partial

  • 中文名称：
    大鼠Slco1a4重组蛋白
  • 货号：
    CSB-YP516590RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Slco1a4重组蛋白
  • 货号：
    CSB-EP516590RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Slco1a4重组蛋白
  • 货号：
    CSB-EP516590RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Slco1a4重组蛋白
  • 货号：
    CSB-BP516590RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Slco1a4重组蛋白
  • 货号：
    CSB-MP516590RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slco1a4
  • Uniprot No.：
  • 别名：
    Slco1a4; Oatp1a4; Oatp2; Slc21a5; Solute carrier organic anion transporter family member 1A4; Brain digoxin carrier protein; Brain-specific organic anion transporter; OATP-B1; Sodium-independent organic anion-transporting polypeptide 2; Solute carrier family 21 member 5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones. May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides.
  • 基因功能参考文献：
    1. Upon chronic/sub-chronic loss of bile excretion, rocuronium clearance via the kidneys is enhanced, by Oatp2 up-regulation. PMID: 28084414
    2. This study demostrated that transport of VPA is mediated by Oatp2. Oatp2 may play an important role in influencing the pharmacological activity of VPA by affecting its uptake and distribution in the brain. PMID: 27156567
    3. Changes in Oatp1a4 functional expression suggest that inflammation in the periphery can modulate blood-brain barrier transporters. PMID: 21131267
    4. Our data provide a basis for the assessment of the role of P-glycoprotein and Oatp2 uptake transporters and efflux pumps in the development of intractable epilepsy. PMID: 19570321
    5. 24S-hydroxycholesterol undergoes elimination from the brain to blood across the blood-brain barrier (BBB) via a carrier-mediated process, which involves oatp2 expressed at the BBB in rats. PMID: 17868302
    6. Suggest that Oatp2 plays a key role in the hepatic uptake of nafcillin and most other beta-lactam antibiotics in rats. PMID: 17891554

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Organo anion transporter (TC 2.A.60) family
  • 组织特异性：
    Highly expressed in brain, liver, and kidney but not expressed in heart, spleen, lung, skeletal muscle, and testis.
  • 数据库链接：

    KEGG: rno:170698

    STRING: 10116.ENSRNOP00000040237

    UniGene: Rn.5641