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  4. Recombinant Rat Syntaxin-binding protein 2 (Stxbp2)

Recombinant Rat Syntaxin-binding protein 2 (Stxbp2)

  • 中文名称：
    大鼠Stxbp2重组蛋白
  • 货号：
    CSB-YP714029RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Stxbp2重组蛋白
  • 货号：
    CSB-EP714029RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Stxbp2重组蛋白
  • 货号：
    CSB-EP714029RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Stxbp2重组蛋白
  • 货号：
    CSB-BP714029RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Stxbp2重组蛋白
  • 货号：
    CSB-MP714029RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Stxbp2
  • Uniprot No.：
  • 别名：
    Stxbp2; Unc18b; Syntaxin-binding protein 2; Protein unc-18 homolog 2; Munc18-2; Unc18-2; Protein unc-18 homolog B; Unc-18B
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-594
  • 氨基酸序列
    MAPLGLKAVV VEKILSGVIR SVKKDGEWKV LIMDHPSMRI LSSCCKMSDI LAEGITIVED INKRREPIPS LEAIYLLSPT EKSVQALIAD FQGTPTFTYK AAHIFFTDTC PEPLFSELGR SRLAKVVKTL KEIHLAFLPY EAQVFSLDAP HSTYNLYCPF RAGERGRQLD VLAQQIATLC ATLQEYPSIR YRKGPEDTAQ LAHAVLAKLN AFKADTPSLG EGPEKTRSQL LIMDRAADPV SPLLHELTFQ AMAYDLLHIE QDTYRYETTG LSESREKAVL LDEDDDLWVE LRHMHIADVS KKVTELLKTF CESKRLTTDK ANIKDLSHIL KKMPQYQKEL NKYSTHLHLA DDCMKHFKGS VEKLCGVEQD LAMGSDAEGE KIKDTMKLIV PVLLDASVPP YDKIRVLLLY ILLRNGVSEE NLAKLIQHAN VQSYSNLIRN LEQLGGTVTN SAGSGTSSRL ERRERMEPTY QLSRWSPVIK DVMEDVVEDR LDRKLWPFVS DPAPVSSSQA AVSSARFGHW HKNKAGIEAR AGPRLIVYIV GGVAMSEMRA AYEVTRATEG KWEVLIGSSH ILTPTRFLDD LRTLDQKLED IALP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
  • 基因功能参考文献：
    1. SNARE zippering requires activation by SNARE-like peptides in Sec1/Munc18 proteins PMID: 30127032
    2. Data show that Munc18b overexpression increased fusion of not only newcomer secretory granule (SG), but also predocked SGs in type-2 diabetes (T2D) human and Goto-Kakizaki Rat Islets. PMID: 28163042
    3. Munc18b-mediated exocytosis may be deployed to increase secretory efficiency of secretory granules in deeper cytosolic layers of beta-cells as well as additional primary exocytosis PMID: 23423569
    4. The results suggest a mechanism for Cab45b action that involves regulating the dynamic association of Munc18b with SNAREs to impact beta-cell granule exocytosis. PMID: 19487699
    5. Mast cells express Munc18-2, which interacts with target SNAREs syntaxin 2 or 3, as well as Munc18-3, which interacts with syntaxin 4. Munc18-2 was localised to secretory granules. PMID: 12482918
    6. These results indicate that mammalian Class C Vps proteins are involved in the regulation of membrane docking and fusion through an interaction with neuronal specific SNARE molecules, nSec-1/Munc18-a and syntaxin 1A. PMID: 17027648
    7. Munc18-2 interaction with syntaxin-3 regulates mast cell degranulation positively during the process of membrane fusion between secretory granules and plasma membrane. PMID: 17408745
    8. In a yeast two-hybrid screen the EF-hand Ca(2+)-binding protein Cab45 was identified as an interaction partner of Munc18b. PMID: 17442889

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  • 蛋白家族：
    STXBP/unc-18/SEC1 family
  • 数据库链接：

    KEGG: rno:81804

    STRING: 10116.ENSRNOP00000001322

    UniGene: Rn.10121