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  4. Recombinant Rat Transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1)

Recombinant Rat Transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1)

  • 中文名称：
    大鼠Tgfb1i1重组蛋白
  • 货号：
    CSB-YP858785RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tgfb1i1重组蛋白
  • 货号：
    CSB-EP858785RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tgfb1i1重组蛋白
  • 货号：
    CSB-EP858785RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tgfb1i1重组蛋白
  • 货号：
    CSB-BP858785RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tgfb1i1重组蛋白
  • 货号：
    CSB-MP858785RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tgfb1i1
  • Uniprot No.：
  • 别名：
    Tgfb1i1; Ara55; Transforming growth factor beta-1-induced transcript 1 protein; Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein; Hic-5
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-461
  • 氨基酸序列
    MEDLDALLSD LETTTSHMSR LGAPKERPPE TLTPPPPYGH QPQTGSGESS GASGDKDHLY STVCKPRSPK SVAPVAPPFS SSSGVLGNGL CELDRLLQEL NATQFNITDE IMSQFPSSKM AEGEGKEDQS EDKSITTVPS STFPAPSKPS ATSATQELDR LMASLSDFRV QNHLPASGPP QPPAVSPTRE GCPSPPGQTN KGSLDTMLGL LQSDLSRRGV PTQAKGLCGS CNKPIAGQVV TALGRAWHPE HFLCRGCSTT LGGSSFFEKD GAPFCPECYF ERFSPRCGFC NQPIRHKMVT ALGTHWHPEH FCCVSCGEPF GEEGFHEREG RPYCRRDFLQ LFAPRCQGCQ GPILDNYISA LSALWHPDCF VCRECLAPFS GGSFFEHEGR PLCENHFHAQ RGSLCATCGL PVTGRCVSAL GRRFHPDHFT CTFCLRPLTK GSFQERASKP YCQPCFLKLF G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
  • 基因功能参考文献：
    1. the reciprocal regulation of MRTF-A localization by Hic-5 and Hic-5 expression by MRTF-A, plays a crucial role in myofibroblast differentiation in response to TGF-beta. PMID: 26759173
    2. these results provide the first evidence for a physical and mutual functional interaction between Hic-5 and the BMP signaling pathway. PMID: 21996749
    3. the C terminus of ARA55 is critical for suppression of Smad3 activity PMID: 15561701
    4. Hic-5 mRNA & protein expression on various days of pregnancy in circular & longitudinal myometrial muscles was measured. It may play a role in focal adhesion remodeling in the rat myometrium during late pregnancy. PMID: 17550607
    5. the association of Hsp27 and Hic-5 are required for the reorganization of the actin cytoskeleton and force development in small arteries PMID: 18083901
    6. These findings demonstrate a novel role for hic-5 in the regulation of actin cytoskeleton and fetal gene expression. PMID: 19540241

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  • 亚细胞定位：
    Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
  • 蛋白家族：
    Paxillin family
  • 组织特异性：
    Strongly expressed in large intestine, lung, spleen, testis, uterus and to a lower extent in brain, kidney and liver (at protein level). In brain, expressed by neuronal and non neuronal cells (at protein level).
  • 数据库链接：

    KEGG: rno:84574

    STRING: 10116.ENSRNOP00000051863

    UniGene: Rn.103260