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  4. Recombinant Rat Transgelin (Tagln)

Recombinant Rat Transgelin (Tagln)

  • 中文名称：
    大鼠Tagln重组蛋白
  • 货号：
    CSB-YP023105RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Tagln重组蛋白
  • 货号：
    CSB-EP023105RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Tagln重组蛋白
  • 货号：
    CSB-EP023105RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Tagln重组蛋白
  • 货号：
    CSB-BP023105RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Tagln重组蛋白
  • 货号：
    CSB-MP023105RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tagln
  • Uniprot No.：
  • 别名：
    Tagln; Sm22; Transgelin; Smooth muscle protein 22-alpha; SM22-alpha
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-201
  • 氨基酸序列
    ANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVMQCGP DVGRPDRGRL GFQVWLKNGV ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA AEDYGVTKTD MFQTVDLFEG KDMAAVQRTV MALGSLAVTK NDGHYRGDPN WFMKKAQEHK REFTDSQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Actin cross-linking/gelling protein.
  • 基因功能参考文献：
    1. CKII-SIRT1-SM22alpha acts in a loop to reinforce the expression of SM22alpha, which limits the inflammatory response in vascular smooth muscle cells. PMID: 28419207
    2. transgelin is up-regulated in the obstructive nephropathy PMID: 23840546
    3. Enhancements in smooth muscle cell properties such as transgelin expression and actomyosin-mediated contractility/motility might be involved in cell survival after NaHS exposure. PMID: 27665774
    4. SM22alpha is a phosphorylation-regulated suppressor of IKK-IkappaBalpha-NF-kappaB signaling cascades. PMID: 25937534
    5. TRAF6-SM22alpha-G6PD pathway is a novel mechanism underlying the association between glucose metabolism and VSMC survival, which is beneficial for vascular repair after injury but facilitates atherosclerotic plaque stability. PMID: 26291555
    6. Speculate that SM22 plays an important role in the regulation of intestinal smooth muscle basal tone via Rho kinase-induced phosphorylation of SM22. PMID: 25617350
    7. Sm22 is present in the cervix of virgin, 11 day, and 20 day pregnant rats. PMID: 25108144
    8. Investigated the role of the TGF-beta receptor and its downstream Smad signaling components that regulate SM22-alpha expression in response to SWCNT induction of VAF differentiation into MFs. PMID: 22904629
    9. Data show that inhibition of SM22alpha phosphorylation abolished the Ang II-activated PKCdelta-p47phox axis and inhibited the hypertrophy and hyperplasia of vascular smooth muscle cells (VSMCs) in vitro and in vivo. PMID: 22798525
    10. SM22alpha acts as a modulator to participate in vascular smooth muscle cell cytoskeleton remodeling. PMID: 21158134
    11. Transgelin in the kidney is upregulated in repopulating mesangial cells in vivo and supports their migratory and proliferative repair response after injury. PMID: 22469697
    12. The recombinant SM22alpha C-terminal domains have the ability to bind F-actin, by which SM22alpha interacts with actin and participates in cytoskeleton reorganization. PMID: 21162287
    13. Data show that SM22alpha was expressed in glomerular epithelial cells and interstitial cells in renal injury. PMID: 20924204
    14. SM22 downregulation can induce proinflammatory vascular smooth muscle cells through activation of ROS-mediated NF-kappaB pathways. PMID: 20224039
    15. The infection of rat carotid arteries with recombinant adenovirus encoding SM22 alpha inhibited neointimal hyperplasia via suppression of the Raf-1-MEK1/2-extracellular signal-regulated kinase 1/2 signaling pathway. PMID: 20139360
    16. loss of transgelin gene expression may be an important early event in tumor progression and a diagnostic marker for breast and colon cancer development. PMID: 11773051
    17. Levels of SM22 alpha mRNA and protein were increased by arginine vasopressin and suppressed by PDGF in vascular smooth muscle cells. PMID: 12829429
    18. A G/C repressor element in the SM22alpha promoter mediates its transcriptional repression in phenotypically modulated SMCs in experimental atherosclerosis. Indirect evidence implicates PDGF-BB & Sp1 as possible mediators of these effects. PMID: 15486317
    19. The injured glomerular epithelial cells in anti-GBM nephritis might undergo structural and functional alterations, including the expression of a smooth muscle marker, SM22alpha. PMID: 17519556
    20. Selective overexpression of airway smooth muscle genes in asthmatic airways leads to increased Vmax, thus contributing to the airway hyperresponsiveness observed in asthma. PMID: 19011151
    21. The single most increased gene was transgelin (Tagln) showing a 70-fold upregulation in animals with passive Heymann nephritis, the best animal model of experimental membranous nephropathy. PMID: 19390219

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Calponin family
  • 组织特异性：
    Smooth muscle and mesenchymal cells but not in skeletal muscle or lymphocytes.
  • 数据库链接：

    KEGG: rno:25123

    STRING: 10116.ENSRNOP00000024030

    UniGene: Rn.34397