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  4. Recombinant Rat Tyrosyl-DNA phosphodiesterase 1 (Tdp1)

Recombinant Rat Tyrosyl-DNA phosphodiesterase 1 (Tdp1)

  • 货号：
    CSB-YP023352RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023352RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023352RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023352RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023352RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Tdp1
  • Uniprot No.：
  • 别名：
    Tdp1; Tyrosyl-DNA phosphodiesterase 1; Tyr-DNA phosphodiesterase 1; EC 3.1.4.-
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-609
  • 氨基酸序列
    MSQESSYGKW TISSSDDSED EKPKPVKPST SSGPQAGQGV SKEPTYTCSE ARKAAHKRQI SPVKFNNTDS VLPHKKQKMD SPEGLGWCLS SSDDEQQPDV TQQEQPKGVP PQEKKYAPSA NVTTAQKVED RSPPDSHRAQ RADEEYETSG EGQDIWDMLD KENPFQFYLT RVSGIKAKYN SKALHIKDIL SPLFGTLVSS AQFNYCFDVN WLIKQYPPEF RKKPILLVHG DKREAKADLH AQAKPYANIS LCQAKLDIAF GTHHTKMMLL LYEEGLRVVI HTSNLIREDW HQKTQGIWLS PLYPRIYQGN HTSGESSTHF KADLTSYLMA YNAPPLQEWI DIIQEHDLSE TNVYLIGSTP GRFQGSHKDN WGHFRLRKLL QAHAPSAPRG ECWPVVGQFS SIGSLGPDES KWLCSEFKES LLAVREEGRT PGRSAVPLHL IYPSVENVRT SLEGYPAGGS LPYGIQTAEK QRWLHPYFHK WSAETSGRSN AMPHIKTYMR PSPDFSKLAW FLVTSANLSK AAWGALEKNG AQLMIRSYEL GVLFLPSAFG LDTFKVKQKF FSSSSEPMAS FPVPYDLPPE LYGSKDRPWI WNIPYVKAPD THGNMWVPS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.
  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Tyrosyl-DNA phosphodiesterase family
  • 数据库链接：

    KEGG: rno:314380

    STRING: 10116.ENSRNOP00000005167

    UniGene: Rn.12661