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  4. Recombinant Rat VIP peptides (Vip)

Recombinant Rat VIP peptides (Vip)

  • 货号：
    CSB-YP355621RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP355621RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP355621RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP355621RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP355621RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Vip
  • Uniprot No.：
  • 别名：
    VipVIP peptides [Cleaved into: Intestinal peptide PHV-42; Intestinal peptide PHI-27; Peptide histidine isoleucinamide 27); Vasoactive intestinal peptide; VIP; Vasoactive intestinal polypeptide)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    81-122
  • 氨基酸序列
    HADGVFTSDY SRLLGQISAK KYLESLIGKR ISSSISEDPV PV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.; PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. PHI also causes vasodilation.
  • 基因功能参考文献：
    1. findings indicate that PACAP and VIP can prevent the deleterious effect of Oxygen/Glucose Deprivation on rat neuronal cells. PMID: 25712659
    2. VIP is an important regulator of cardiovascular and digestive system in physiological and pathological conditions PMID: 25990439
    3. Data support the role of VIP as a local neuromodulator released by intrinsic enteric neurons and responsible for the induction of IGN through a VPAC1 receptor-dependent mechanism in enterocytes. PMID: 25586379
    4. Alterations in VIP expression may play a role in trinitrobenzene sulfonic acid-induced colitis. PMID: 25574088
    5. Data suggest long-term dietary L-arginine supplementation up-regulates VIP and eNOS (endothelial nitric oxide synthase) in mucosa small intestine (particularly in enterocytes and interstitial cells of Cajal) undergoing adaptation to cold temperature. PMID: 24100601
    6. Stimulating hippocampal microglia with the peptide neurotransmitter VIP via VPAC1 receptors increases production of IL-4 which promotes their trophic and proliferative effects on neural stem/progenitor cells PMID: 24801739
    7. Our findings point to a predominant involvement of the right hippocampal CA1 area in the positive effect of VIP on learning and memory impairments of rats with an OBX model of depression rats PMID: 22160165
    8. VIP had protective effects on severe acute pancreatitis gut barrier function. PMID: 21725849
    9. VIP was found in many neurons and fibers of the sphenopalatine ganglion PMID: 22108610
    10. Treatment with VIP reduces brain damage in ischemic rats, an effect that may be associated with attenuation of apoptosis and expression of S100 protein beta (S100B) polypeptide. PMID: 21620378
    11. Report age-related changes in myosin-V myenteric neurons, CGRP and VIP immunoreactivity in the ileum of rats supplemented with ascorbic acid. PMID: 22127604
    12. PACAP and VIP induce morphological and functional differentiation of embryonic stem cells into a neuronal phenotype PMID: 22001490
    13. Estradiol attenuated acute lung injury in three experimental models while stimulating VIP gene expression PMID: 22009726
    14. These results suggest that the nitric oxide-cyclic GMP pathway differentially regulates vasoactive intestinal peptide in the dentate gyrus DG and hippocampus during seizure. PMID: 20369387
    15. VIP elevated SP-A expression in ATII cells which was mediated by enhanced sp-a gene transcription PMID: 20688121
    16. Conclude that the spontaneous release of VIP from the enteric motor neurons maintains homeostasis in smooth muscle function in mild inflammation by blocking the activation of NF-kappaB. PMID: 19661154
    17. Data show that the light synchronization process in the suprachiasmatic nucleus involves a selective remodelling of synapses at sites of photic integration, including VIP neurons. PMID: 20074215
    18. voltage-gated Ca(2+) channels (VGCCs) responsible for the non-adrenergic non-cholinergic (NANC) relaxation and vasoactive intestinal polypeptide (VIP)-like immunoreactivity release in the rat gastric fundus PMID: 19945453
    19. Cultured female rat pituitary cells were treated with 10 nM 1,17 beta-estradiol or triiodothyronine. E2 treatment for 3 days resulted in a 5-fold increase in VIP mRNA. In contrast, T(3) treatment reduced the mRNA levels of VIP to 40% of control values. PMID: 12147214
    20. In the basolateral amygdala, VIP-positive (VIP+) axon terminals form synaptic-like contacts with calbindin-positive (CB+) neurons, and with pyramidal neurons. PMID: 12528187
    21. VIP promoted survival of myenteric neurons in culture. PMID: 12609771
    22. Changes of substance P and VIP levels in initial part of ileum and blood of spleen deficiency rats and cool stress rats may be closely related to the gastrointestinal motility disorders presented in spleen deficiency and cool stress rats. PMID: 12632517
    23. Not only does VIP alter the intrathalamic rhythmic activity, this peptide that is endogenous to the thalamic circuit may also play a significant role in the regulation of information transfer through the thalamocortical circuit. PMID: 12711712
    24. Increases in the spinal levels of VIP and NPY after peripheral nerve injury were not sufficient for the development of neuropathic pain. PMID: 12727330
    25. Pituitary VIP mediates the effect of estrogen on lactotroph hyperplasia, pituitary TGF-beta1, and angiogenesis. PMID: 12960047
    26. Plasma VIP significantly decreased at postinjury 3, 12 and 24 hours, but significantly increased at 72 hours and declined on day 7. In jejunum significantly increased at 3 hours postinjury and declined at 12 and 24 hours, but increased at 72 hours. PMID: 15040036
    27. The increased nonadrenergic noncholinergic and the decreased effects of VIP in mediating inhibitory nerves may largely relate to the peristaltic abnormalities seen in the isografted LEW rat jejunum. PMID: 15050161
    28. Aging reduces vasoactive intestinal peptide (VIP) receptor mRNA and eliminates diurnal expression of VIP mRNA within the suprachiasmatic nucleus of aged male rats. PMID: 15344914
    29. VIP can modulate not only immune responses but also hormonal responses during acute inflammation. PMID: 15467350
    30. VIP had a modulatory action on jejunal potassium absorption when injected into the nucleus tractus solitarius. PMID: 15627496
    31. Significant changes in NPY and VIP prostate nerve fibers, showing an increase in periurethral ducts at sex maturation. PMID: 15716245
    32. Involved in regulating the proliferation of prolactin-secreting cells, in an in vitro study on monolayer cultures of rat pituitary cells. PMID: 16328361
    33. Intra-articular injection of VIP into normal rat knee joints caused pain responses & VPAC antagonists abolished them. VIP may be involved in the generation of osteoarthritis pain. PMID: 16564620
    34. pituitary adenylate cyclase-activating polypeptidergic mechanisms within the pontine reticular formation play a critical role in long-term regulation of rapid eye movement sleep PMID: 16888155
    35. adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide are differentially regulated and are involved in the regulatory processes under a food-restricted regimen, and are differentially altered in nocturnal and diurnal species PMID: 16888191
    36. Activation of c-Jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to pathogenesis of neuropathic pain following chronic constriction injury. PMID: 17081520
    37. Small bowel transplantation (SBT) decreased response to exogenous Substance P, although release of endogenous Substance P (EFS) is preserved. Changes in VIP signaling are acute and reversible and not caused by effects of SBT PMID: 17512547
    38. Footshock stress decreased the number of cells expressing VIP mRNA in the SCN without changing hybridization level per cell. PMID: 17826907
    39. Chronic atropine administration diminishes the contribution of vasoactive intestinal polypeptide to heart rate regulation. PMID: 18052688
    40. Hippocampal asymmetry in exploratory behavior to Vip is reported. PMID: 18321609
    41. Data demonstrate PACAP and PAC1, but not VIP, regulation in micturition pathways with inflammation and PACAP-mediated ATP release from urothelium. PMID: 18563302
    42. Data show that the role of VIP in claustral development is assoicated with the regulation of neuronal proliferation and differentiation. PMID: 18598846
    43. Data show that in enteric nerves anandamide stimulates VIP release by activation of a CB2 receptor specific pathway, while the stimulation of NO production suggests the existence of an additional type of cannabinoid receptor in the enteric nervous system. PMID: 18829105
    44. Our results suggested that both PACAP38 and VIP could act as trophic factors in Schwann cells. PMID: 18835258
    45. Release of regulatory gut peptide vasoactive intestinal peptide by acid and hyperosmolal solutions in the intestine in conscious rats PMID: 18992283
    46. The results showed that VIP, PACAP-38, PACAP-27 and the VPAC(1) specific agonist evoked significant dilations with the rank order of potency; VIP = PACAP-38 > PACAP-27 = [Lys15, Arg16, Leu27]-VIP(1-7)-GRF(8-27). PMID: 19220306
    47. Treatment with VIP enhances angiogenesis in the ischemic brain, and this effect may be mediated by increases in levels of VEGF and its receptors. PMID: 19332106

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glucagon family
  • 数据库链接：

    KEGG: rno:117064

    STRING: 10116.ENSRNOP00000025477

    UniGene: Rn.18675