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  4. Recombinant Rat Vascular endothelial growth factor B (Vegfb)

Recombinant Rat Vascular endothelial growth factor B (Vegfb)

  • 货号：
    CSB-YP025834RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP025834RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP025834RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP025834RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP025834RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Vegfb; VrfVascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-207
  • 氨基酸序列
    PVSQFDGPS HQKKVVSWID VYARATCQPR EVVVPLSMEL MGNVVKQLVP SCVTVQRCGG CCPDDGLECV PIGQHQVRMQ ILMIQYPSSQ LGEMSLEEHS QCECRPKRKE SAVKPDRVAI PHHRPQPRSV LSWDSAPGAS SPADIIHPTP APGPSAHAAP SAVSALIPGP AVAAADAAAS SIAKGGA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
  • 基因功能参考文献：
    1. Loss of VEGFB and its downstream signaling is an early event following hyperglycemia, is sustained with disease progression, and could explain diabetic cardiomyopathy. PMID: 28314760
    2. Data suggest that dietary fatty acids create epigenetic/nutrigenomic changes in methylation levels of CpG island at Vegfb promoter and changes in Vegfb expression in white adipocytes in vivo and in vitro, with particular up-regulation of DNA methylation by linoleic acid; Vegfb promoter methylation levels are closely related to Vegfb gene expression in visceral and subcutaneous adipose tissue. PMID: 26707994
    3. Cardiac VEGF-B mRNA expression decreases following heart transplantation. PMID: 23141860
    4. VEGF-B has important effects on the functional architecture of the visual cortex. PMID: 23370270
    5. results demonstrate that the vascular endothelium can function as an efficient barrier to excess muscle lipid uptake even under conditions of severe obesity and type 2 diabetes, and that this barrier can be maintained by inhibition of VEGF-B signalling PMID: 23023133
    6. VEGFB and PlGF can either inhibit or potentiate the actions of VEGFA, depending on their relative concentrations, which change in the hypoxic lung. PMID: 21266048
    7. VEGF-B appears to be a coronary growth factor in rats but not in mice. PMID: 20937974

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 数据库链接：

    KEGG: rno:89811

    STRING: 10116.ENSRNOP00000049757

    UniGene: Rn.198550