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  4. Recombinant Rat Vascular endothelial growth factor receptor 3 (Flt4), partial

Recombinant Rat Vascular endothelial growth factor receptor 3 (Flt4), partial

  • 中文名称：
    大鼠Flt4重组蛋白
  • 货号：
    CSB-YP846017RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Flt4重组蛋白
  • 货号：
    CSB-EP846017RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Flt4重组蛋白
  • 货号：
    CSB-EP846017RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Flt4重组蛋白
  • 货号：
    CSB-BP846017RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Flt4重组蛋白
  • 货号：
    CSB-MP846017RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Flt4; Flt-4; Vegfr3; Vascular endothelial growth factor receptor 3; VEGFR-3; EC 2.7.10.1; Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
  • 基因功能参考文献：
    1. The findings of this study suggest an important role for VEGFC/VEGFR3 signaling in neuronal proliferation in early forebrain development, and ongoing functions with niche neurogenesis, glial and ependymal function in the maturing postnatal brain. PMID: 25943477
    2. Expression of VEGFR-3 is enhanced in various cell types of the infarcted heart. PMID: 22818386
    3. lymph node-specific antibody-mediated inhibition of VEGFR-3 activation in response to VEGF-C draining to the nodes from metastatic MT-450 tumors inhibited the outgrowth but not initiation of metastases in these nodes. PMID: 24379135
    4. vasculature-associated VEGFR-3-expressing cells in the ischemic core may represent a heterogeneous population of cells with functional diversity, rather than a uniform cell type PMID: 22771250
    5. VEGF-C/VEGFR-3 signaling modulated innate and adaptive immune responses in the development of obliterative bronchiolitis in rat tracheal allografts. PMID: 22959907
    6. VEGFR-3 is involved in the recruitment of monocytic macrophages and in glial reactions during experimental autoimmune encephalomyelitis. PMID: 22983493
    7. The present study presents, to our knowledge, the first detailed mapping of VEGFR-3 mRNA expression in adult rat brain and spinal cord PMID: 21703344
    8. VEGFR-3 has even broader functions than previously thought, regulating both developmental processes and adult neuronal function in the cerebellum. PMID: 21072582
    9. The data of this study suggested that VEGFR-3 may be involved in the glial reaction and possibly in the recruitment of monocytic macrophages during ischemic insults. PMID: 20692049
    10. VEGFR-3 might mediate the regulation of both neurogenesis and adult neuronal function in the rat forebrain and eye. PMID: 20127810
    11. These data indicate that VEGFR-3 is upregulated in subventricular zone astrocytes and immature neurons after focal ischemia, suggesting that VEGFR-3 might mediate the adult neurogenesis after ischemic stroke. PMID: 19963036
    12. Immunostaining for the specific lymphatic markers VEGFR-3 revealed an extensive lymphatic vessel system in dental tissues. Unexpected cell staining for the above lymphatic markers was found in the pulp of both molars and incisors in rats. PMID: 19196316

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
  • 数据库链接：

    KEGG: rno:114110

    STRING: 10116.ENSRNOP00000003519

    UniGene: Rn.81043