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  4. Recombinant Regulatory protein E2 (E2)

Recombinant Regulatory protein E2 (E2)

  • 货号：
    CSB-YP768849HNK
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP768849HNK
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP768849HNK-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP768849HNK
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP768849HNK
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    E2
  • Uniprot No.：
  • 别名：
    E2; Regulatory protein E2
  • 种属：
    Human papillomavirus type 38
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-441
  • 氨基酸序列
    METLSARFTV LQEKLMDIYE SGVEDLDTQI QHWQLLRQEQ IIYHYARRHG VTRLGYQPVP SLASSEAKAK DAISMVLLLE SLKKSKYADE QWTLAQTSLE AVRSPPADCF KKGPKNIEVV FDGDPENLMS YTVWTYIYYL TDEDIWEKVE GHVDYTGAYY YEGKLKVYYL KFENDAKRYG VTGLWEVHVN KDTVFTPVTS STPPVGDSTD SASRAALPEP STSVSPERPP SQTARRYGRK ASSPSTTSRR QRKGQRETTG TQRRRKSRSR SRSTNRGGRD TRRSSSRGSS VSPTRGRRRG GGDSRRRGPV TRSRSRSLSR ASSAGGGISP DKVGTAVRSV GRQSGGRLTR LLADAADPPV ILLRGDANTL KCYRYRFRKK HAGGFRFVST TWSWIGDASN DRIGRSRMLL AFYSESQREK FIQTMKLPTG VEWSLGQFDD L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
  • 亚细胞定位：
    Host nucleus.
  • 蛋白家族：
    Papillomaviridae E2 protein family