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  4. Recombinant Saccharomyces cerevisiae Uncharacterized protein YMR111C (YMR111C)

Recombinant Saccharomyces cerevisiae Uncharacterized protein YMR111C (YMR111C)

  • 中文名称：
    酿酒酵母YMR111C重组蛋白
  • 货号：
    CSB-YP311995SVG
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    酿酒酵母YMR111C重组蛋白
  • 货号：
    CSB-EP311995SVG
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    酿酒酵母YMR111C重组蛋白
  • 货号：
    CSB-EP311995SVG-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    酿酒酵母YMR111C重组蛋白
  • 货号：
    CSB-BP311995SVG
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    酿酒酵母YMR111C重组蛋白
  • 货号：
    CSB-MP311995SVG
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    YMR111C
  • Uniprot No.：
  • 别名：
    EUC1; YMR111C; YM9718.10CTranscription factor-like protein EUC1; Enriches ubiquitin on chromatin protein 1
  • 种属：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-462
  • 氨基酸序列
    MPAREYNYVE GFGGYGSLDD DDSDRDSERR NHDLGQRTIT TSPTGVSRHA ALNRYMIPGR INPLFRPTDA AQPPIVSTST SASATEPTNR IGPGRIKETP ETNFNAFLIA QLTRMEEQNA NLKEEISLMK KEQELFFLEN QKKLEKGFKD INKYVEDVSA MKEVFKEVVG IMTGERIRFI DHTGENVTPQ EAARVGNPST STQAHQSQSR STNWQEYSMH ASILAGDPRI KPEPGLSDFE NGEYDGNESD ENATTRNLPL NNPDSVSNAD DSNNQLDGTG NENDIRNRRG CVGTSYKLNR AIQNVTDAAR EYFEGLPGQP SVLSLERRYG STWRRSAKER TLFTKRMTII KRIIDIKDDP SKYGLSLPEN KISRNQAIKV VENIRLGNNT FKGHHCRLSM SQLYEYFSKK MDKLEDYSLT LKRRGKPRRI FLLEEREARL SLQQPHSIPN SSTGTPEHDQ DT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor-like protein that binds to specific DNA motifs called ub-HS-motif associated with several locations where proteins other than histone H2B are ubiquitinated (ub-hotspots). Ubiquitination at these sites depends on the SUMO-targeted ubiquitin ligase (STUbL) complex SLX5/SLX8 and protein turnover on the CDC48 segregase. UBC9, SIZ1, or SIZ2 sumoylate DNA-bound EUC1 to stabilize its DNA-binding. Sumoylated EUC1 acts a cofactor required for the recruitment of the SLX5/SLX8 STUbL complex via specific contacts between EUC1 and SLX5, as well as an additional SUMO-mediated interaction. SLX5/SLX8 then ubiquitinates EUC1 and presumably other targets at ub-hotspots, and the CDC48/UFD1/NPL4 complex, together with UBX4 and UBX5, removes Lys-48-linked ubiquitinated proteins from chromatin. Ubiquitinated proteins could be either degraded by the proteasome or recycled by deubiquitination. EUC1 itself does not seem to underlie extensive turnover, as it is a very stable protein. EUC1 is able to act as a transcription factor, but its function at ub-hotspots does not seem to depend on this ability. EUC1-mediated ub-hotspots are crucial during stress responses when gene expression control is impaired.
  • 亚细胞定位：
    Chromosome.
  • 数据库链接：

    KEGG: sce:YMR111C

    STRING: 4932.YMR111C