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  4. Recombinant Salmonella typhimurium Chaperone protein sicA (sicA)

Recombinant Salmonella typhimurium Chaperone protein sicA (sicA)

  • 货号：
    CSB-YP304779SXB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP304779SXB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP304779SXB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP304779SXB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP304779SXB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    sicA
  • Uniprot No.：
  • 别名：
    sicA; spaT; STM2886; Chaperone protein SicA; Salmonella invasin chaperone
  • 种属：
    Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-165
  • 氨基酸序列
    MDYQNNVSEE RVAEMIWDAV SEGATLKDVH GIPQDMMDGL YAHAYEFYNQ GRLDEAETFF RFLCIYDFYN PDYTMGLAAV CQLKKQFQKA CDLYAVAFTL LKNDYRPVFF TGQCQLLMRK AAKARQCFEL VNERTEDESL RAKALVYLEA LKTAETEQHS EQEKE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Type III secretion-associated chaperone required for SipB and SipC stabilization. Prevents premature association of SipB with SipC, which may lead to their targeting for degradation. Along with InvF, required for transcription activation of sigDE (sopB pipC), sicAsipBCDA, and sopE.
  • 基因功能参考文献：
    1. Investigated whether the tetratricopeptide repeat-like motifs in SicA are critical for transcriptional cofactor function. The canonical residues in these motifs were mutated to glutamate (SicAA44E , SicAA78E , and SicAG112E ). PMID: 24224875
    2. crystal of SicA belonged to the monoclinic space group C2, with unit-cell parameters a = 180.4, b = 94.1, c = 131.8 A, beta = 130.9 degrees PMID: 21045315
    3. SicA chaperone binds to SipB somewhere between amino acids 80 and 100 of the SipB N-terminal region. PMID: 17768243
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    LcrH/SycD chaperone family
  • 数据库链接：

    KEGG: stm:STM2886

    STRING: 99287.STM2886