Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Schizosaccharomyces pombe Peroxiredoxin tpx1 (tpx1)

Recombinant Schizosaccharomyces pombe Peroxiredoxin tpx1 (tpx1)

  • 中文名称：
    庞贝裂殖酵母tpx1重组蛋白
  • 货号：
    CSB-YP524904SXV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    庞贝裂殖酵母tpx1重组蛋白
  • 货号：
    CSB-EP524904SXV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    庞贝裂殖酵母tpx1重组蛋白
  • 货号：
    CSB-EP524904SXV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    庞贝裂殖酵母tpx1重组蛋白
  • 货号：
    CSB-BP524904SXV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    庞贝裂殖酵母tpx1重组蛋白
  • 货号：
    CSB-MP524904SXV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    tpx1
  • Uniprot No.：
  • 别名：
    tpx1; tsa1; SPCC576.03c; Peroxiredoxin tpx1; EC 1.11.1.15; Thioredoxin peroxidase; TPx
  • 种属：
    Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-192
  • 氨基酸序列
    MSLQIGKPAP DFKGTAVVNG AFEEIKLADY KGKWVFLGFY PLDFTFVCPT EIVAFSEAAS KFAERNAQVI LTSTDSEYSH LAFINTPRKE GGLGGINIPL LADPSHKVSR DYGVLIEDAG VAFRGLFLID PKGVLRQITI NDLPVGRSVD EALRLLDAFQ FVEEHGEVCP ANWHKGSDTI DTKNPEKYFS KH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Relays hydrogen peroxide as a signal to the transcription factor pap1 by inducing the formation of intramolecular disulfide bonds in pap1, which causes its nuclear accumulation and activation. Reduced by srx1 and this regulation acts as a molecular switch controlling the transcriptional response to hydrogen peroxide.
  • 基因功能参考文献：
    1. our data establish that redox-coupling between Trx1 and the thioredoxin peroxidase activity of Tpx1 is central for initiation of appropriate responses to different levels of hydrogen peroxide in S. pombe PMID: 22245228
    2. Thioredoxin Peroxidase inhibited thermal aggregation of citrate synthase, but BCP failed to inhibit the aggregation. PMID: 20356456
    3. redox regulation of the thioredoxin peroxidase activity of Tpx1 acts as a molecular switch controlling the transcriptional response to H(2)O(2) PMID: 15824112
    4. The peroxiredoxin Tpx1 is an upstream activator of Pap1. Tpx1 oxidation to the cysteine-sulfinic acid constitutes a previously uncharacterized redox switch in H2O2 signaling, restricting Pap1 activation within a narrow range of H2O2 concentrations. [Tpx1] PMID: 15956211
    5. Prx protein is partly responsible for maintaining low ROS level under normal and stressful growth conditions in the fission yeast PMID: 17530441
    6. the carboxy-terminal extension of Tpx1 concomitantly improves H2O2 scavenging and increases susceptibility to inactivation PMID: 18233959

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 数据库链接：

    KEGG: spo:SPCC576.03c

    STRING: 4896.SPCC576.03c.1